NP_001231567.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,282 Da
NCBI Official Full Name
AT-rich interactive domain-containing protein 5B isoform 2
NCBI Official Synonym Full Names
AT rich interactive domain 5B (MRF1-like)
NCBI Protein Information
AT-rich interactive domain-containing protein 5B; MRF1-like protein; ARID domain-containing protein 5B; modulator recognition factor 2 (MRF2)
UniProt Protein Name
AT-rich interactive domain-containing protein 5B
UniProt Synonym Protein Names
MRF1-like protein; Modulator recognition factor 2; MRF-2
UniProt Synonym Gene Names
UniProt Entry Name
ARI5B_HUMAN
NCBI Summary for ARID5B
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for ARID5B
Mrf-2: Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population. Defects in ARID5B may be a cause of susceptibility to acute lymphoblastic leukemia (ALL). ALL is a subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes. Belongs to the ARID5B family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; transcription coactivator activity
Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; adrenal gland development; multicellular organism growth; male gonad development; platelet-derived growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; palate development; liver development; post-embryonic development; regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; positive regulation of transcription factor activity; kidney development; negative regulation of transcription, DNA-dependent; cell development; muscle morphogenesis; female gonad development
Research Articles on ARID5B
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Products associated with anti-ARID5B antibody
Pathways associated with anti-ARID5B antibody
Diseases associated with anti-ARID5B antibody
Organs/Tissues associated with anti-ARID5B antibody
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