P36405.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ADP-ribosylation factor-like protein 3
NCBI Official Synonym Full Names
ADP-ribosylation factor-like 3
NCBI Official Synonym Symbols
NCBI Protein Information
ADP-ribosylation factor-like protein 3; ARF-like 3
UniProt Protein Name
ADP-ribosylation factor-like protein 3
UniProt Synonym Gene Names
UniProt Entry Name
ARL3_HUMAN
NCBI Summary for ARL3
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]
UniProt Comments for ARL3
ARL3: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. Belongs to the small GTPase superfamily. Arf family.
Protein type: Cytoskeletal; Cell cycle regulation; G protein, monomeric; G protein, monomeric, ARF
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: Golgi membrane; Golgi apparatus; centrosome; cytoplasmic microtubule; spindle microtubule; midbody; nucleus; photoreceptor connecting cilium
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; microtubule binding; metal ion binding
Biological Process: photoreceptor cell development; protein transport; smoothened signaling pathway; metabolic process; small GTPase mediated signal transduction; organelle organization and biogenesis; intraflagellar transport; cytokinesis; post-Golgi vesicle-mediated transport; kidney development
Research Articles on ARL3
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Products associated with anti-ARL3 antibody
Pathways associated with anti-ARL3 antibody
Diseases associated with anti-ARL3 antibody
Organs/Tissues associated with anti-ARL3 antibody
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