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anti-ARMET antibody :: Goat ARMET Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421407
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARMET, Polyclonal Antibody

 Also Known As   

Goat anti-ARMET Antibody

 Product Synonym Names    ARMET; arginine-rich, mutated in early stage tumors; ARP; MANF; MGC142148; MGC142150; arginine-rich protein; ARMET antibody; arginine-rich; mutated in early stage tumors antibody; ARP antibody; MANF antibody; MGC142148 antibody; MGC142150 antibody; arginine-rich protein antibody
 Product Gene Name   

anti-ARMET antibody

[Similar Products]
 Antibody/Peptide Pairs    ARMET peptide (MBS426908) is used for blocking the activity of ARMET antibody (MBS421407)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KFCREARGKE NR
 OMIM    601916
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KFCREARGKENR, from the internal region of the protein sequence according to NP_006001.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ARMET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARMET antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ARMET antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 21kDa band observed in Human Pancreas lysates (calculated MW of 21.1kDa according to NP_006001.2). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-ARMET antibody    (0.3ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ARMET antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ARMET. It may not necessarily be applicable to this product.
 NCBI GI #    54873600
 NCBI GeneID    7873
 NCBI Accession #    NP_006001.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006010.3 [Other Products]
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 UniProt Secondary Accession #    Q14CX4; Q86U67; Q96IS4 [Other Products]
 UniProt Related Accession #    P55145 [Other Products]
 Molecular Weight    20,700 Da
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 NCBI Official Full Name    mesencephalic astrocyte-derived neurotrophic factor
 NCBI Official Synonym Full Names    mesencephalic astrocyte derived neurotrophic factor
 NCBI Official Symbol    MANF [Similar Products]
 NCBI Official Synonym Symbols   
ARP; ARMET
[Similar Products]
 NCBI Protein Information    mesencephalic astrocyte-derived neurotrophic factor
 UniProt Protein Name    Mesencephalic astrocyte-derived neurotrophic factor
 UniProt Synonym Protein Names   
Arginine-rich protein; Protein ARMET
 UniProt Gene Name    MANF [Similar Products]
 UniProt Synonym Gene Names    ARMET; ARP [Similar Products]
 UniProt Entry Name    MANF_HUMAN
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 NCBI Summary for ARMET    The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
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 UniProt Comments for ARMET    ARMET: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Belongs to the ARMET family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular region; nucleus

Molecular Function: growth factor activity

Biological Process: response to unfolded protein

Disease: Pancreatic Cancer
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 Research Articles on ARMET    1. MANF is a protein that interacts with RTN1-C
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ARMET antibodyOrgans/Tissues associated with anti-ARMET antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >18 publications with ARMET and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >10 publications with ARMET and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >9 publications with ARMET and Nerve Degeneration
 Kidney Diseases Antibodies  >3 publications with ARMET and Kidney Diseases
 Inflammation Antibodies  >3 publications with ARMET and Inflammation
 Necrosis Antibodies  >3 publications with ARMET and Necrosis
 Adenocarcinoma Antibodies  >2 publications with ARMET and Adenocarcinoma
 Hypertrophy Antibodies  >2 publications with ARMET and Hypertrophy
 Lung Neoplasms Antibodies  >2 publications with ARMET and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with ARMET and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >70 publications with ARMET and Nerve
 Brain Antibodies  >33 publications with ARMET and Brain
 Embryonic Tissue Antibodies  >7 publications with ARMET and Embryonic Tissue
 Blood Antibodies  >6 publications with ARMET and Blood
 Kidney Antibodies  >3 publications with ARMET and Kidney
 Heart Antibodies  >3 publications with ARMET and Heart
 Vascular Antibodies  >3 publications with ARMET and Vascular
 Bone Antibodies  >3 publications with ARMET and Bone
 Lung Antibodies  >2 publications with ARMET and Lung
 Connective Tissue Antibodies  >1 publications with ARMET and Connective Tissue
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