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anti-ARMS2 antibody :: Goat ARMS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422328 anti-ARMS2 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARMS2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-ARMS2 Antibody

 Product Synonym Names    ARMS2; age-related maculopathy susceptibility 2; ARMD8; age-related maculopathy susceptibility 2 antibody; ARMD8 antibody; ARMS2 antibody
 Product Gene Name   

anti-ARMS2 antibody

[Similar Products]
 Antibody/Peptide Pairs    ARMS2 peptide (MBS427231) is used for blocking the activity of ARMS2 antibody (MBS422328)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EGASDKQRSK
 OMIM    611313
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EGASDKQRSK, from the internal region of the protein sequence according to NP_001093137.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ARMS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARMS2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-ARMS2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as small as the calculated size of 11.4kDa according to NP_001093137.1. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.
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NCBI/Uniprot data below describe general gene information for ARMS2. It may not necessarily be applicable to this product.
 NCBI GI #    153792797
 NCBI GeneID    387715
 NCBI Accession #    NP_001093137.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001099667.1 [Other Products]
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 UniProt Secondary Accession #    B2Y7I5 [Other Products]
 UniProt Related Accession #    P0C7Q2 [Other Products]
 Molecular Weight    11,437 Da
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 NCBI Official Full Name    age-related maculopathy susceptibility protein 2
 NCBI Official Synonym Full Names    age-related maculopathy susceptibility 2
 NCBI Official Symbol    ARMS2 [Similar Products]
 NCBI Official Synonym Symbols   
ARMD8
[Similar Products]
 NCBI Protein Information    age-related maculopathy susceptibility protein 2
 UniProt Protein Name    Age-related maculopathy susceptibility protein 2
 Protein Family    Age-related maculopathy susceptibility protein
 UniProt Gene Name    ARMS2 [Similar Products]
 UniProt Entry Name    ARMS2_HUMAN
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 NCBI Summary for ARMS2    This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ARMS2    ARMS2: Defects in ARMS2 influence susceptibility to age-related macular degeneration type 8 (ARMD8). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: mitochondrion; photoreceptor inner segment

Biological Process: retinal homeostasis

Disease: Macular Degeneration, Age-related, 8
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 Research Articles on ARMS2    1. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ARMS2 antibodyOrgans/Tissues associated with anti-ARMS2 antibody
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >322 publications with ARMS2 and Macular Degeneration
 Inflammation Antibodies  >11 publications with ARMS2 and Inflammation
 Hypercholesterolemia Antibodies  >3 publications with ARMS2 and Hypercholesterolemia
 Heart Diseases Antibodies  >3 publications with ARMS2 and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with ARMS2 and Kidney Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with ARMS2 and Neurodegenerative Diseases
 Atherosclerosis Antibodies  >2 publications with ARMS2 and Atherosclerosis
 Myocardial Infarction Antibodies  >1 publications with ARMS2 and Myocardial Infarction
 Nerve Degeneration Antibodies  >1 publications with ARMS2 and Nerve Degeneration
 Hearing Loss Antibodies  >1 publications with ARMS2 and Hearing Loss
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >4 publications with ARMS2 and Placenta
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