NP_001184254.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 87 kDa Predicted: 87 kDa
NCBI Official Full Name
aryl hydrocarbon receptor nuclear translocator isoform 4
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator
NCBI Official Synonym Symbols
HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta [Similar Products]
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta
UniProt Synonym Gene Names
NCBI Summary for ARNT
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
UniProt Comments for ARNT
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Research Articles on ARNT
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Products associated with anti-ARNT antibody
Pathways associated with anti-ARNT antibody
Diseases associated with anti-ARNT antibody
Organs/Tissues associated with anti-ARNT antibody
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