NP_001284653.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,136 Da
NCBI Official Full Name
aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator-like
NCBI Official Synonym Symbols
TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5 [Similar Products]
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator-like protein 1; ARNT-like protein 1, brain and muscle; PAS domain-containing protein 3; bHLH-PAS protein JAP3; basic-helix-loop-helix-PAS orphan MOP3; basic-helix-loop-helix-PAS protein MOP3; brain and muscle ARNT-like 1; class E basic helix-loop-helix protein 5; member of PAS protein 3; member of PAS superfamily 3
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Synonym Protein Names
Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
UniProt Synonym Gene Names
UniProt Entry Name
BMAL1_HUMAN
NCBI Summary for ARNTL
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for ARNTL
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: PML body; transcription factor complex; nucleus
Molecular Function: signal transducer activity; protein binding; DNA binding; aryl hydrocarbon receptor binding; sequence-specific DNA binding; protein heterodimerization activity; bHLH transcription factor binding; Hsp90 protein binding
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; regulation of cell cycle; positive regulation of transcription, DNA-dependent; response to redox state; positive regulation of circadian rhythm; negative regulation of fat cell differentiation; signal transduction; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of insulin secretion
Research Articles on ARNTL
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ARNTL antibody
Diseases associated with anti-ARNTL antibody
Organs/Tissues associated with anti-ARNTL antibody
|