NP_001120977.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 44kDa; 46kDa Observed: 46kDa
NCBI Official Full Name
acid ceramidase isoform c
NCBI Official Synonym Full Names
N-acylsphingosine amidohydrolase 1
NCBI Official Synonym Symbols
AC; PHP; ASAH; PHP32; ACDase; SMAPME [Similar Products]
NCBI Protein Information
acid ceramidase
UniProt Protein Name
Acid ceramidase
UniProt Synonym Protein Names
Acylsphingosine deacylase; N-acylsphingosine amidohydrolase; Putative 32 kDa heart protein; PHP32
UniProt Synonym Gene Names
NCBI Summary for ASAH1
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
UniProt Comments for ASAH1
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Research Articles on ASAH1
Precautions
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Disclaimer
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Products associated with anti-ASAH1 antibody
Pathways associated with anti-ASAH1 antibody
Diseases associated with anti-ASAH1 antibody
Organs/Tissues associated with anti-ASAH1 antibody
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