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anti-ASCC1 antibody :: Rabbit anti-Human ASCC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493303
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASCC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ASCC1 Antibody

 Product Synonym Names    Activating signal cointegrator 1 complex subunit 1; ASCC1; CGI-18; ASC-1 complex subunit p50; Trip4 complex subunit p50
 Product Gene Name   

anti-ASCC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614215
 3D Structure    ModBase 3D Structure for Q8N9N2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Activating signal cointegrator 1 complex subunit 1 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160156
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ASCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ASCC1 antibody

   Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin.
 Applications Tested/Suitable for anti-ASCC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ASCC1 antibody    Recommended dilution: IHC:1:20-1:200
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 Western Blot (WB) of anti-ASCC1 antibody    Western Blot
Positive WB detected in:Hela whole cell lysate,HEK293 whole cell lysate,Jurkat whole cell lysate,Mouse heart tissue,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue,Mouse stomach tissue
All lanes: ASCC1 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46,42 kDa
Observed band size: 46 kDa

anti-ASCC1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ASCC1 antibody    Immunohistochemistry of paraffin-embedded human tonsil using MBS1493303 at dilution of 1:100
anti-ASCC1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ASCC1. It may not necessarily be applicable to this product.
 NCBI GI #    311771708
 NCBI GeneID    51008
 NCBI Accession #    NP_001185727.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198798.2 [Other Products]
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 UniProt Primary Accession #    Q8N9N2 [Other Products]
 UniProt Secondary Accession #    Q5SW06; Q5SW07; Q96EI8; Q9Y307 [Other Products]
 UniProt Related Accession #    Q8N9N2 [Other Products]
 Molecular Weight    41,228 Da
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 NCBI Official Full Name    activating signal cointegrator 1 complex subunit 1 isoform b
 NCBI Official Synonym Full Names    activating signal cointegrator 1 complex subunit 1
 NCBI Official Symbol    ASCC1 [Similar Products]
 NCBI Official Synonym Symbols   
p50; CGI-18; ASC1p50
[Similar Products]
 NCBI Protein Information    activating signal cointegrator 1 complex subunit 1
 UniProt Protein Name    Activating signal cointegrator 1 complex subunit 1
 UniProt Synonym Protein Names   
ASC-1 complex subunit p50; Trip4 complex subunit p50
 Protein Family    Activating signal cointegrator 1 complex
 UniProt Gene Name    ASCC1 [Similar Products]
 UniProt Entry Name    ASCC1_HUMAN
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 NCBI Summary for ASCC1    This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for ASCC1    ASCC1: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Defects in ASCC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in ASCC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10pter-q25.3

Cellular Component: cytoplasm; nucleoplasm; transcription factor complex

Molecular Function: protein binding; RNA binding

Biological Process: DNA dealkylation; DNA repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Barrett Esophagus
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 Research Articles on ASCC1    1. Three major genes, MSR1, ASCC1, and CTHRC1 were associated with Barrett esophagus/esophageal adenocarcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ASCC1 antibodyPathways associated with anti-ASCC1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >1 publications with ASCC1 and JUN
 Products by Pathway  Pathway Diagram
 ALKBH3 Mediated Reversal Of Alkylation Damage Pathway antibodies  ALKBH3 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram
Diseases associated with anti-ASCC1 antibodyOrgans/Tissues associated with anti-ASCC1 antibody
 Disease Name  Pubmed Publications
 Digestive System Abnormalities Antibodies  >1 publications with ASCC1 and Digestive System Abnormalities
 Carcinoma Antibodies  >1 publications with ASCC1 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Esophagus Antibodies  >2 publications with ASCC1 and Esophagus
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