Q9Y294.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,969 Da
NCBI Official Full Name
Histone chaperone ASF1A
NCBI Official Synonym Full Names
anti-silencing function 1A histone chaperone
NCBI Protein Information
histone chaperone ASF1A
UniProt Protein Name
Histone chaperone ASF1A
UniProt Synonym Protein Names
Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA
UniProt Synonym Gene Names
UniProt Entry Name
ASF1A_HUMAN
NCBI Summary for ASF1A
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
UniProt Comments for ASF1A
ASF1A: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family.
Protein type: Histone-binding; DNA repair, damage
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; histone binding; protein binding
Biological Process: chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; muscle cell differentiation; negative regulation of chromatin silencing; nucleosome assembly; osteoblast differentiation; transcription, DNA-dependent
Research Articles on ASF1A
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Products associated with anti-ASF1A antibody
Pathways associated with anti-ASF1A antibody
Diseases associated with anti-ASF1A antibody
Organs/Tissues associated with anti-ASF1A antibody
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