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anti-ASH1 antibody :: Rabbit ASH1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS855947
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASH1, Polyclonal Antibody

 Also Known As   

ASH1 Antibody

 Product Gene Name   

anti-ASH1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100790
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Lyophilized anti-ASH1 antibody purified by peptide affinity column containing 0.5% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal ASH1 (1) antibody was raised against a 16 amino acid peptide from near the C terminal residues of human ASH1 protein.
 Reactivity Note    Not yet tested in other species.
 Pathway    achaete-scute complex homolog 1
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 Other Notes    Small volumes of anti-ASH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ASH1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ASH1 antibody   

Western Blot (WB)

 Application Notes for anti-ASH1 antibody    Peptide ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-500
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-ASH1 antibody    anti-ASH1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ASH1. It may not necessarily be applicable to this product.
 NCBI GI #    55743094
 NCBI GeneID    429
 NCBI Accession #    NP_004307 [Other Products]
 NCBI GenBank Nucleotide #    NM_004316.3 [Other Products]
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 UniProt Secondary Accession #    Q9BQ30; A8K3C4 [Other Products]
 UniProt Related Accession #    P50553 [Other Products]
 Molecular Weight    25,454 Da
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 NCBI Official Full Name    achaete-scute homolog 1
 NCBI Official Synonym Full Names    achaete-scute family bHLH transcription factor 1
 NCBI Official Symbol    ASCL1 [Similar Products]
 NCBI Official Synonym Symbols   
ASH1; HASH1; MASH1; bHLHa46
[Similar Products]
 NCBI Protein Information    achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46
 UniProt Protein Name    Achaete-scute homolog 1
 UniProt Synonym Protein Names   
Class A basic helix-loop-helix protein 46; bHLHa46
 Protein Family    Hemolysin
 UniProt Gene Name    ASCL1 [Similar Products]
 UniProt Synonym Gene Names    ASH1; BHLHA46; HASH1; ASH-1; hASH1; bHLHa46 [Similar Products]
 UniProt Entry Name    ASCL1_HUMAN
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 NCBI Summary for ASH1    This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ASH1    ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cell soma; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity

Biological Process: vestibular nucleus development; musculoskeletal movement, spinal reflex action; response to lithium ion; cell maturation; olfactory pit development; regulation of mitotic cell cycle; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; response to folic acid; positive regulation of neuron apoptosis; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; regulation of timing of subpallium neuron differentiation; positive regulation of cell cycle; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; regulation of gene expression; subpallium neuron fate commitment; commitment of a neuronal cell to a specific type of neuron in the forebrain; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Central Hypoventilation Syndrome, Congenital
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Product References and Citations for anti-ASH1 antibody

   (1)Somasundaram,K. Reddy,S.P., Vnnakota,K Upregulation of ASCL1 and inhibition of Notch signaling pathway haracterize progressive astrocytoma.Oncogene.24 (47), 7073-7083 (2005).
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 Research Articles on ASH1    1. ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ASH1 antibodyPathways associated with anti-ASH1 antibody
 Reference Product  PubMed Publications
 HES1 antibody  >58 publications with ASH1 and HES1
 NOTCH1 antibody  >42 publications with ASH1 and NOTCH1
 SHH antibody  >19 publications with ASH1 and SHH
 HES6 antibody  >8 publications with ASH1 and HES6
 SYP antibody  >3 publications with ASH1 and SYP
 GLI2 antibody  >3 publications with ASH1 and GLI2
 TLE1 antibody  >2 publications with ASH1 and TLE1
 UBQLN1 antibody  >1 publications with ASH1 and UBQLN1
 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-ASH1 antibodyOrgans/Tissues associated with anti-ASH1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >51 publications with ASH1 and Lung Diseases
 Nervous System Diseases Antibodies  >51 publications with ASH1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >21 publications with ASH1 and Disease Models, Animal
 Death Antibodies  >18 publications with ASH1 and Death
 Prostatic Diseases Antibodies  >9 publications with ASH1 and Prostatic Diseases
 Cell Transformation, Neoplastic Antibodies  >7 publications with ASH1 and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >6 publications with ASH1 and Hyperplasia
 Liver Neoplasms Antibodies  >6 publications with ASH1 and Liver Neoplasms
 Liver Diseases Antibodies  >5 publications with ASH1 and Liver Diseases
 Prenatal Exposure Delayed Effects Antibodies  >4 publications with ASH1 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >214 publications with ASH1 and Brain
 Nerve Antibodies  >195 publications with ASH1 and Nerve
 Embryonic Tissue Antibodies  >100 publications with ASH1 and Embryonic Tissue
 Lung Antibodies  >68 publications with ASH1 and Lung
 Eye Antibodies  >52 publications with ASH1 and Eye
 Thyroid Antibodies  >31 publications with ASH1 and Thyroid
 Pancreas Antibodies  >4 publications with ASH1 and Pancreas
 Kidney Antibodies  >1 publications with ASH1 and Kidney
 Lymph Node Antibodies  >1 publications with ASH1 and Lymph Node
 Thymus Antibodies  >1 publications with ASH1 and Thymus
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