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anti-ASL antibody :: Rabbit anti-Human ASL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9412831
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASL, Polyclonal Antibody

★Popular Item★
 Also Known As   

ASL Antibody

 Product Synonym Names    ASAL
 Product Gene Name   

anti-ASL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    207900
 3D Structure    ModBase 3D Structure for P04424
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous levels of total ASL protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    1.4 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Fusion protein corresponding to residues near the C terminal of human argininosuccinate lyase
 Target Name    ASL
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-ASL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ASL antibody

   This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
 Product Categories/Family for anti-ASL antibody    Total protein Ab
 Applications Tested/Suitable for anti-ASL antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-ASL antibody    Immunohistochemistry: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-ASL antibody    Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/35.
anti-ASL antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ASL antibody    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/35.
anti-ASL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ASL. It may not necessarily be applicable to this product.
 NCBI GI #    31541964
 NCBI GeneID    435
 NCBI Accession #    NP_000039.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000048.3 [Other Products]
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 UniProt Primary Accession #    P04424 [Other Products]
 UniProt Secondary Accession #    Q6LDS5; Q96HS2; E7EMI0; E9PE48 [Other Products]
 UniProt Related Accession #    P04424 [Other Products]
 Molecular Weight    48,733 Da
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 NCBI Official Full Name    argininosuccinate lyase isoform 1
 NCBI Official Synonym Full Names    argininosuccinate lyase
 NCBI Official Symbol    ASL [Similar Products]
 NCBI Official Synonym Symbols   
ASAL
[Similar Products]
 NCBI Protein Information    argininosuccinate lyase
 UniProt Protein Name    Argininosuccinate lyase
 UniProt Synonym Protein Names   
Arginosuccinase
 UniProt Gene Name    ASL [Similar Products]
 UniProt Synonym Gene Names    ASAL [Similar Products]
 UniProt Entry Name    ARLY_HUMAN
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 NCBI Summary for ASL    This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ASL    ASL: Defects in ASL are the cause of arginosuccinic aciduria (ARGINSA). An autosomal recessive disorder of the urea cycle. The disease is characterized by mental and physical retardation, liver enlargement, skin lesions, dry and brittle hair showing trichorrhexis nodosa microscopically and fluorescing red, convulsions, and episodic unconsciousness. Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Protein type: EC 4.3.2.1; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: cytoplasm; cytosol

Molecular Function: argininosuccinate lyase activity

Biological Process: arginine catabolic process; arginine biosynthetic process via ornithine; internal protein amino acid acetylation; urea cycle

Disease: Argininosuccinic Aciduria
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 Research Articles on ASL    1. Point mutation of ASS1, ASL and SLC25A13 is associated with citrullinemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ASL antibodyPathways associated with anti-ASL antibody
 Reference Product  PubMed Publications
 OTC antibody  >17 publications with ASL and OTC
 CAD antibody  >12 publications with ASL and CAD
 ASS1 antibody  >11 publications with ASL and ASS1
 CPS1 antibody  >7 publications with ASL and CPS1
 ARG1 antibody  >6 publications with ASL and ARG1
 NAGS antibody  >5 publications with ASL and NAGS
 OAT antibody  >4 publications with ASL and OAT
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 L-citrulline-nitric Oxide Cycle Pathway antibodies  L-citrulline-nitric Oxide Cycle Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-ASL antibodyOrgans/Tissues associated with anti-ASL antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >444 publications with ASL and Brain Diseases
 Fibrosis Antibodies  >182 publications with ASL and Fibrosis
 Kidney Diseases Antibodies  >127 publications with ASL and Kidney Diseases
 Liver Diseases Antibodies  >126 publications with ASL and Liver Diseases
 Inflammation Antibodies  >108 publications with ASL and Inflammation
 Hypertension Antibodies  >104 publications with ASL and Hypertension
 Disease Models, Animal Antibodies  >80 publications with ASL and Disease Models, Animal
 Hemorrhage Antibodies  >77 publications with ASL and Hemorrhage
 Liver Neoplasms Antibodies  >66 publications with ASL and Liver Neoplasms
 Necrosis Antibodies  >63 publications with ASL and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1266 publications with ASL and Blood
 Brain Antibodies  >821 publications with ASL and Brain
 Vascular Antibodies  >523 publications with ASL and Vascular
 Heart Antibodies  >309 publications with ASL and Heart
 Lung Antibodies  >296 publications with ASL and Lung
 Liver Antibodies  >205 publications with ASL and Liver
 Kidney Antibodies  >177 publications with ASL and Kidney
 Muscle Antibodies  >119 publications with ASL and Muscle
 Bone Antibodies  >116 publications with ASL and Bone
 Skin Antibodies  >97 publications with ASL and Skin
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