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anti-ASXL1 antibody :: Rabbit anti-Mouse ASXL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211148
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASXL1, Polyclonal Antibody

 Also Known As   

ASXL1 Antibody (Center)

 Product Synonym Names    Putative Polycomb group protein ASXL1; Additional sex combs-like protein 1; ASXL1; KIAA0978
 Product Gene Name   

anti-ASXL1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ASXL1 peptide (MBS9218168) is used for blocking the activity of ASXL1 antibody (MBS9211148)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    521-549
 OMIM    605039
 3D Structure    ModBase 3D Structure for Q8IXJ9
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    This ASXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.43 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ASXL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ASXL1 antibody

   This gene is similar to the Drosophila additional sex
combs gene, which encodes a chromatin-binding protein required for
normal determination of segment identity in the developing embryo.
The protein is a member of the Polycomb group of proteins, which
are necessary for the maintenance of stable repression of homeotic
and other loci. The protein is thought to disrupt chromatin in
localized areas, enhancing transcription of certain genes while
repressing the transcription of other genes. The protein encoded by
this gene functions as a ligand-dependent co-activator for retinoic
acid receptor in cooperation with nuclear receptor coactivator 1.
Mutations in this gene are associated with myelodysplastic
syndromes and chronic myelomonocytic leukemia. Alternative splicing
results in multiple transcript variants.
 Product Categories/Family for anti-ASXL1 antibody    Signal Transduction
 Applications Tested/Suitable for anti-ASXL1 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-ASXL1 antibody    WB~~1:1000
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 Western Blot (WB) of anti-ASXL1 antibody    ASXL1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the ASXL1 antibody detected the ASXL1 protein (arrow).
anti-ASXL1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ASXL1 antibody    ASXL1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ASXL1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ASXL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-ASXL1 antibody    ASXL1 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ASXL1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunofluorescence (IF) of anti-ASXL1 antibody    Confocal immunofluorescent analysis of ASXL1 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
anti-ASXL1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ASXL1. It may not necessarily be applicable to this product.
 NCBI GI #    29570782
 NCBI GeneID    171023
 NCBI Accession #    NP_056153.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015338.5 [Other Products]
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 UniProt Primary Accession #    Q8IXJ9 [Other Products]
 UniProt Secondary Accession #    Q5JWS9; Q8IYY7; Q9H466; Q9NQF8; Q9UFJ0; Q9UFP8; Q9Y2I4; B2RP59 [Other Products]
 UniProt Related Accession #    Q8IXJ9 [Other Products]
 Molecular Weight    165448
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 NCBI Official Full Name    putative Polycomb group protein ASXL1 isoform 1
 NCBI Official Synonym Full Names    additional sex combs like transcriptional regulator 1
 NCBI Official Symbol    ASXL1 [Similar Products]
 NCBI Official Synonym Symbols   
MDS; BOPS
[Similar Products]
 NCBI Protein Information    putative Polycomb group protein ASXL1
 UniProt Protein Name    Putative Polycomb group protein ASXL1
 UniProt Synonym Protein Names   
Additional sex combs-like protein 1
 Protein Family    Putative Polycomb group protein
 UniProt Gene Name    ASXL1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0978 [Similar Products]
 UniProt Entry Name    ASXL1_HUMAN
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 NCBI Summary for ASXL1    This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
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 UniProt Comments for ASXL1    ASXL1: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Defects in ASXL1 are the cause of Bohring-Opitz syndrome (BOPS). A syndrome characterized by severe intrauterine growth retardation, poor feeding, profound mental retardation, trigonocephaly, prominent metopic suture, exophthalmos, nevus flammeus of the face, upslanting palpebral fissures, hirsutism, and flexion of the elbows and wrists with deviation of the wrists and metacarpophalangeal joints. Defects in ASXL1 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Belongs to the Asx family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: nuclear chromatin

Molecular Function: peroxisome proliferator activated receptor binding; protein binding; DNA binding; retinoic acid receptor binding; metal ion binding; transcription coactivator activity; transcription corepressor activity

Biological Process: negative regulation of retinoic acid receptor signaling pathway; response to retinoic acid; transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation

Disease: Bohring-opitz Syndrome; Myelodysplastic Syndrome
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Product References and Citations for anti-ASXL1 antibody

   Abdel-Wahab, O., et al. Leukemia 24(9):1656-1657(2010)
Szpurka, H., et al. Leuk. Res. 34(8):969-973(2010)
Sugimoto, Y., et al. Br. J. Haematol. 150(1):83-87(2010)
Boultwood, J., et al. Leukemia 24(6):1139-1145(2010)
Rocquain, J., et al. BMC Cancer 10, 401 (2010) :
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 Research Articles on ASXL1    1. SETBP1 mutations are critical drivers of ASXL1-mutated myelodysplastic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ASXL1 antibodyOrgans/Tissues associated with anti-ASXL1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >33 publications with ASXL1 and Anemia
 Cell Transformation, Neoplastic Antibodies  >28 publications with ASXL1 and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >8 publications with ASXL1 and Congenital Abnormalities
 Fibrosis Antibodies  >5 publications with ASXL1 and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with ASXL1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with ASXL1 and Neurobehavioral Manifestations
 Skin Diseases Antibodies  >3 publications with ASXL1 and Skin Diseases
 Leukopenia Antibodies  >3 publications with ASXL1 and Leukopenia
 Bohring syndrome Antibodies  >3 publications with ASXL1 and Bohring syndrome
 Hypertension Antibodies  >2 publications with ASXL1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with ASXL1 and Blood
 Bone Antibodies  >50 publications with ASXL1 and Bone
 Bone Marrow Antibodies  >48 publications with ASXL1 and Bone Marrow
 Lung Antibodies  >4 publications with ASXL1 and Lung
 Liver Antibodies  >3 publications with ASXL1 and Liver
 Prostate Antibodies  >3 publications with ASXL1 and Prostate
 Heart Antibodies  >3 publications with ASXL1 and Heart
 Skin Antibodies  >2 publications with ASXL1 and Skin
 Embryonic Tissue Antibodies  >2 publications with ASXL1 and Embryonic Tissue
 Spleen Antibodies  >2 publications with ASXL1 and Spleen
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