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anti-ATF6 antibody :: Rabbit anti-Human, Mouse ATF6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242041
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATF6, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ATF6

 Product Synonym Names    Anti-ATF6 Antibody (N-Terminus) IHC-plus; ATF6; ATF6-alpha; ATF6A; Human ATF6
 Product Gene Name   

anti-ATF6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605537
 3D Structure    ModBase 3D Structure for P18850
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    17 amino acid peptide from near the amino terminus of human ATF6
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human ATF6.
 Immunogen Type    Synthetic peptide
 Immunogen    ATF6 antibody was raised against synthetic peptide from human ATF6.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-ATF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ATF6 antibody

   Activating Transcription Factor 6 (ATF6) is a type II transmembrane glycoprotein located on the ER membrane. In response to ER stress ATF6 is cleaved and the N-terminus including the leucine zipper (which faces the cytosol) moves to the nucleus. Once in the nucleus ATF6 binds to the ER stress response elements in ER stress genes. Site-1 and site-2 protease enzymes that process sterol regulatory binding proteins in response to cholesterol derivation cleave ATF6.
 Applications Tested/Suitable for anti-ATF6 antibody   

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ATF6 antibody    ELISA, ICC, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ATF6 antibody    Anti-ATF6 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ATF6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-ATF6 antibody    Immunocytochemistry of ATF6 in A20 with ATF6 antibody at 10 ug/ml.
anti-ATF6 antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-ATF6 antibody    Western blot of ATF6 in MDA-MB-361 cell lysate with ATF6 antibody at (A) 0.5 and (B) 1 ug/ml.
anti-ATF6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ATF6. It may not necessarily be applicable to this product.
 NCBI GI #    56786157
 NCBI GeneID    22926
 NCBI Accession #    NP_031374.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007348.3 [Other Products]
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 UniProt Primary Accession #    P18850 [Other Products]
 UniProt Secondary Accession #    O15139; Q5VW62; Q6IPB5; Q9UEC9 [Other Products]
 UniProt Related Accession #    P18850 [Other Products]
 Molecular Weight    74,585 Da
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 NCBI Official Full Name    cyclic AMP-dependent transcription factor ATF-6 alpha
 NCBI Official Synonym Full Names    activating transcription factor 6
 NCBI Official Symbol    ATF6 [Similar Products]
 NCBI Official Synonym Symbols   
ATF6A
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-6 alpha
 UniProt Synonym Protein Names   
Activating transcription factor 6 alpha; ATF6-alpha
 Protein Family    Cyclic AMP-dependent transcription factor
 UniProt Gene Name    ATF6 [Similar Products]
 UniProt Synonym Gene Names    cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha [Similar Products]
 UniProt Entry Name    ATF6A_HUMAN
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 NCBI Summary for ATF6    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
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 UniProt Comments for ATF6    ATF6A: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. Belongs to the bZIP family. ATF subfamily.

Protein type: Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane; nuclear envelope; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; transcription, DNA-dependent; protein folding; unfolded protein response; positive regulation of transcription of target genes involved in unfolded protein response; response to stress; signal transduction

Disease: Achromatopsia 7
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 Research Articles on ATF6    1. Data shows that mutation of putative p38 MAPK phosphorylation sites in ATF6 suppresses its transcriptional induction of DAPK1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATF6 antibodyPathways associated with anti-ATF6 antibody
 Reference Product  PubMed Publications
 DDIT3 antibody  >201 publications with ATF6 and DDIT3
 HSPA5 antibody  >31 publications with ATF6 and HSPA5
 YY1 antibody  >7 publications with ATF6 and YY1
 CALR antibody  >3 publications with ATF6 and CALR
 SREBF2 antibody  >3 publications with ATF6 and SREBF2
 MBTPS2 antibody  >3 publications with ATF6 and MBTPS2
 MBTPS1 antibody  >2 publications with ATF6 and MBTPS1
 MAPK14 antibody  >1 publications with ATF6 and MAPK14
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-ATF6 antibodyOrgans/Tissues associated with anti-ATF6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >50 publications with ATF6 and Inflammation
 Liver Diseases Antibodies  >45 publications with ATF6 and Liver Diseases
 Brain Diseases Antibodies  >38 publications with ATF6 and Brain Diseases
 Necrosis Antibodies  >33 publications with ATF6 and Necrosis
 Heart Diseases Antibodies  >26 publications with ATF6 and Heart Diseases
 Lung Diseases Antibodies  >22 publications with ATF6 and Lung Diseases
 Insulin Resistance Antibodies  >21 publications with ATF6 and Insulin Resistance
 Fibrosis Antibodies  >18 publications with ATF6 and Fibrosis
 Hyperglycemia Antibodies  >16 publications with ATF6 and Hyperglycemia
 Atherosclerosis Antibodies  >16 publications with ATF6 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >81 publications with ATF6 and Liver
 Blood Antibodies  >65 publications with ATF6 and Blood
 Brain Antibodies  >65 publications with ATF6 and Brain
 Muscle Antibodies  >56 publications with ATF6 and Muscle
 Heart Antibodies  >50 publications with ATF6 and Heart
 Vascular Antibodies  >45 publications with ATF6 and Vascular
 Pancreas Antibodies  >36 publications with ATF6 and Pancreas
 Lung Antibodies  >27 publications with ATF6 and Lung
 Bone Antibodies  >25 publications with ATF6 and Bone
 Eye Antibodies  >22 publications with ATF6 and Eye
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