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anti-ATG12 antibody :: Rabbit ATG12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223608
Unit / Price
0.05 mg  /  $275 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATG12, Polyclonal Antibody

 Also Known As   

RABBIT ANTI ATG12 (N-TERMINAL)

 Product Gene Name   

anti-ATG12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide corresponding to a 16 aa sequence from near the amino terminus of human ATG12.
Histology Positive Control Tissue
 Antiserum Preparation    Antiserum to human ATG12 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ATG12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ATG12 antibody

   Rabbit anti ATG12 (N-Terminal) antibody recognizes human Autophagy-related protein 12 (ATG12). ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA, inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. There are at least two isoforms of ATG12.
 Applications Tested/Suitable for anti-ATG12 antibody   

Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-ATG12 antibody    Western Blot: This item detects a band of approximately 40 kDa in human brain tissue lysate.
Immunohistology - Paraffin: Minimum Dilution: 2.5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1ug/ml
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 Testing Data #1 of anti-ATG12 antibody    Western blot analysis of human brain lysate probed with Rabbit anti Human ATG12 (MBS223848) at 0.5(A) and 1(B) ug/ml
anti-ATG12 antibody Testing Data #1 image
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 Testing Data #2 of anti-ATG12 antibody    Immunohistochemical staining of human brain with Rabbit anti Human ATG12 (MBS223848)
anti-ATG12 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for ATG12. It may not necessarily be applicable to this product.
 NCBI GI #    84042517
 NCBI GeneID    361321
 NCBI Accession #    NP_001033584.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001038495.1 [Other Products]
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 UniProt Secondary Accession #    Q5M9F9 [Other Products]
 UniProt Related Accession #    Q2TBJ5 [Other Products]
 Molecular Weight    15,284 Da
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 NCBI Official Full Name    ubiquitin-like protein ATG12
 NCBI Official Synonym Full Names    autophagy related 12
 NCBI Official Symbol    Atg12 [Similar Products]
 NCBI Official Synonym Symbols   
Apg12l
[Similar Products]
 NCBI Protein Information    ubiquitin-like protein ATG12; ATG12 autophagy related 12 homolog; autophagy-related 12; autophagy-related protein 12
 UniProt Protein Name    Ubiquitin-like protein ATG12
 UniProt Synonym Protein Names   
Autophagy-related protein 12; APG12-like
 Protein Family    Autophagy protein
 UniProt Gene Name    Atg12 [Similar Products]
 UniProt Synonym Gene Names    Apg12l; APG12-like [Similar Products]
 UniProt Entry Name    ATG12_RAT
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 UniProt Comments for ATG12    Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus ().
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to RABBIT ANTI ATG12 (N-TERMINAL)
 Catalog #  Product Name  Catalog #  Product Name
 MBS9223201  ATG12 Antibody (N-term) Blocking peptide  MBS807602  Rabbit Anti-Human ATG12 Polyclonal
 MBS807743  Rabbit Anti-Human ATG12 Polyclonal  MBS807676  Rabbit Anti-Human ATG12 Polyclonal
 MBS223563  RABBIT ANTI ATG12 (INTERNAL REGION)  MBS807554  Rabbit Anti-Human ATG12 Polyclonal
 MBS9203753  ATG12 Antibody (N-term)  MBS6003354  ATG12, NT (ATG12, APG12, APG12L, Ubiquitin-like protein ATG12, Autophagy-related protein 12)
 MBS807519  Rabbit Anti-Human ATG12 Polyclonal  MBS807766  Rabbit Anti-Human ATG12 Polyclonal
Products associated with anti-ATG12 antibodyPathways associated with anti-ATG12 antibody
 Reference Product  PubMed Publications
 Atg5 antibody  >229 publications with ATG12 and Atg5
 Atg7 antibody  >87 publications with ATG12 and Atg7
 Atg3 antibody  >47 publications with ATG12 and Atg3
 Becn1 antibody  >38 publications with ATG12 and Becn1
 Atg16l1 antibody  >36 publications with ATG12 and Atg16l1
 Atg10 antibody  >31 publications with ATG12 and Atg10
 Atg4b antibody  >10 publications with ATG12 and Atg4b
 Tecpr1 antibody  >4 publications with ATG12 and Tecpr1
 Ddx58 antibody  >4 publications with ATG12 and Ddx58
 Visa antibody  >2 publications with ATG12 and Visa
 Products by Pathway  Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
Diseases associated with anti-ATG12 antibodyOrgans/Tissues associated with anti-ATG12 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with ATG12 and Nervous System Diseases
 Inflammation Antibodies  >11 publications with ATG12 and Inflammation
 Breast Neoplasms Antibodies  >10 publications with ATG12 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with ATG12 and Cardiovascular Diseases
 Necrosis Antibodies  >9 publications with ATG12 and Necrosis
 Liver Diseases Antibodies  >8 publications with ATG12 and Liver Diseases
 Adenocarcinoma Antibodies  >7 publications with ATG12 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >6 publications with ATG12 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >5 publications with ATG12 and Heart Diseases
 Muscular Diseases Antibodies  >5 publications with ATG12 and Muscular Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >27 publications with ATG12 and Muscle
 Brain Antibodies  >25 publications with ATG12 and Brain
 Liver Antibodies  >15 publications with ATG12 and Liver
 Heart Antibodies  >11 publications with ATG12 and Heart
 Kidney Antibodies  >6 publications with ATG12 and Kidney
 Prostate Antibodies  >6 publications with ATG12 and Prostate
 Pancreas Antibodies  >2 publications with ATG12 and Pancreas
 Eye Antibodies  >2 publications with ATG12 and Eye
 Connective Tissue Antibodies  >2 publications with ATG12 and Connective Tissue
 Dorsal Root Ganglion Antibodies  >2 publications with ATG12 and Dorsal Root Ganglion
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