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anti-ATG16L1 antibody :: Rabbit anti-Human ATG16L1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002154
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATG16L1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ATG16L1 Antibody

 Product Synonym Names    Autophagy-related protein 16-1; APG16-like 1; ATG16L1; APG16L
 Product Gene Name   

anti-ATG16L1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610767
 3D Structure    ModBase 3D Structure for Q676U5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Autophagy-related protein 16-1 protein(1-607AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70133 / sc-70134
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ATG16L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATG16L1 antibody

   Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
 Applications Tested/Suitable for anti-ATG16L1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ATG16L1 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-ATG16L1 antibody    Immunohistochemistry of paraffin-embedded human skin tissue using MBS7002154 at dilution 1:100
anti-ATG16L1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ATG16L1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer tissue using MBS7002154 at dilution 1:100
anti-ATG16L1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.
 NCBI GI #    298229005
 NCBI GeneID    55054
 NCBI Accession #    NP_001177195.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190266.1 [Other Products]
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 UniProt Primary Accession #    Q676U5 [Other Products]
 UniProt Secondary Accession #    Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0 [Other Products]
 UniProt Related Accession #    Q676U5 [Other Products]
 Molecular Weight    49,486 Da
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 NCBI Official Full Name    autophagy-related protein 16-1 isoform 4
 NCBI Official Synonym Full Names    autophagy related 16 like 1
 NCBI Official Symbol    ATG16L1 [Similar Products]
 NCBI Official Synonym Symbols   
IBD10; WDR30; APG16L; ATG16A; ATG16L
[Similar Products]
 NCBI Protein Information    autophagy-related protein 16-1
 UniProt Protein Name    Autophagy-related protein 16-1
 UniProt Synonym Protein Names   
APG16-like 1
 Protein Family    Autophagy-related protein
 UniProt Gene Name    ATG16L1 [Similar Products]
 UniProt Synonym Gene Names    APG16L [Similar Products]
 UniProt Entry Name    A16L1_HUMAN
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 NCBI Summary for ATG16L1    The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
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 UniProt Comments for ATG16L1    ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, peripheral; Autophagy

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: autophagic vacuole; axoneme; cytosol; pre-autophagosomal structure membrane

Molecular Function: identical protein binding; protein binding; small conjugating protein ligase activity

Biological Process: autophagic vacuole formation; macroautophagy; protein homooligomerization; protein transport

Disease: Inflammatory Bowel Disease 10
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 Research Articles on ATG16L1    1. ATG16L1 may be used as a biomarker for selecting oral squamous cell carcinoma patients with a more aggressive phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATG16L1 antibodyPathways associated with anti-ATG16L1 antibody
 Reference Product  PubMed Publications
 NOD2 antibody  >152 publications with ATG16L1 and NOD2
 ATG5 antibody  >62 publications with ATG16L1 and ATG5
 ATG12 antibody  >42 publications with ATG16L1 and ATG12
 ULK1 antibody  >20 publications with ATG16L1 and ULK1
 SQSTM1 antibody  >14 publications with ATG16L1 and SQSTM1
 RAB33B antibody  >6 publications with ATG16L1 and RAB33B
 RAB33A antibody  >3 publications with ATG16L1 and RAB33A
 RB1CC1 antibody  >3 publications with ATG16L1 and RB1CC1
 TMEM59 antibody  >1 publications with ATG16L1 and TMEM59
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-ATG16L1 antibodyOrgans/Tissues associated with anti-ATG16L1 antibody
 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >228 publications with ATG16L1 and Inflammatory Bowel Diseases
 Crohn Disease Antibodies  >192 publications with ATG16L1 and Crohn Disease
 Inflammation Antibodies  >85 publications with ATG16L1 and Inflammation
 Inflammatory Bowel Disease 10 Antibodies  >55 publications with ATG16L1 and Inflammatory Bowel Disease 10
 Necrosis Antibodies  >28 publications with ATG16L1 and Necrosis
 Disease Models, Animal Antibodies  >17 publications with ATG16L1 and Disease Models, Animal
 Death Antibodies  >9 publications with ATG16L1 and Death
 Liver Diseases Antibodies  >7 publications with ATG16L1 and Liver Diseases
 Fibrosis Antibodies  >5 publications with ATG16L1 and Fibrosis
 Nervous System Diseases Antibodies  >5 publications with ATG16L1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >64 publications with ATG16L1 and Intestine
 Blood Antibodies  >45 publications with ATG16L1 and Blood
 Liver Antibodies  >12 publications with ATG16L1 and Liver
 Brain Antibodies  >8 publications with ATG16L1 and Brain
 Bone Antibodies  >7 publications with ATG16L1 and Bone
 Nerve Antibodies  >6 publications with ATG16L1 and Nerve
 Muscle Antibodies  >6 publications with ATG16L1 and Muscle
 Heart Antibodies  >5 publications with ATG16L1 and Heart
 Bone Marrow Antibodies  >4 publications with ATG16L1 and Bone Marrow
 Skin Antibodies  >3 publications with ATG16L1 and Skin
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