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anti-ATG4C antibody :: Rabbit anti-Human, Mouse ATG4C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493458
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATG4C, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human ATG4C polyclonal Antibody

 Product Synonym Names    AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; ATG4C; APG4C; AUTL1; AUTL3
 Product Gene Name   

anti-ATG4C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611339
 3D Structure    ModBase 3D Structure for Q96DT6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Cysteine protease ATG4C protein (259-458aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-163708 / sc-163707
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ATG4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATG4C antibody

   Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
 Applications Tested/Suitable for anti-ATG4C antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ATG4C antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-ATG4C antibody    Western blot
All lanes: ATG4C antibody at 9ug/ml
Lane 1:mouse lung tissue
Lane 2:HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 52kDa
Observed band size: 52kDa

anti-ATG4C antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ATG4C antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1493458 at dilution 1:100
anti-ATG4C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ATG4C. It may not necessarily be applicable to this product.
 NCBI GI #    30410844
 NCBI GeneID    84938
 NCBI Accession #    NP_116241.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032852.3 [Other Products]
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 UniProt Primary Accession #    Q96DT6 [Other Products]
 UniProt Secondary Accession #    Q96K04; A6NLR8; D3DQ58 [Other Products]
 UniProt Related Accession #    Q96DT6 [Other Products]
 Molecular Weight    52,497 Da
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 NCBI Official Full Name    cysteine protease ATG4C
 NCBI Official Synonym Full Names    autophagy related 4C, cysteine peptidase
 NCBI Official Symbol    ATG4C [Similar Products]
 NCBI Official Synonym Symbols   
APG4C; AUTL1; AUTL3; APG4-C
[Similar Products]
 NCBI Protein Information    cysteine protease ATG4C
 UniProt Protein Name    Cysteine protease ATG4C
 UniProt Synonym Protein Names   
AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C
 Protein Family    Cysteine protease
 UniProt Gene Name    ATG4C [Similar Products]
 UniProt Synonym Gene Names    APG4C; AUTL1; AUTL3 [Similar Products]
 UniProt Entry Name    ATG4C_HUMAN
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 NCBI Summary for ATG4C    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ATG4C    ATG4C: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family.

Protein type: Protease; EC 3.4.22.-; Autophagy; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: cytoplasm; cytosol; extracellular region

Molecular Function: cysteine-type endopeptidase activity; peptidase activity

Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis
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 Research Articles on ATG4C    1. miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATG4C antibodyPathways associated with anti-ATG4C antibody
 Reference Product  PubMed Publications
 ATG3 antibody  >6 publications with ATG4C and ATG3
 GABARAPL1 antibody  >3 publications with ATG4C and GABARAPL1
 GABARAPL2 antibody  >3 publications with ATG4C and GABARAPL2
 MAP1LC3B antibody  >1 publications with ATG4C and MAP1LC3B
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
Diseases associated with anti-ATG4C antibodyOrgans/Tissues associated with anti-ATG4C antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >9 publications with ATG4C and Death
 Heart Diseases Antibodies  >2 publications with ATG4C and Heart Diseases
 Inflammation Antibodies  >2 publications with ATG4C and Inflammation
 Carcinoma Antibodies  >1 publications with ATG4C and Carcinoma
 Cardiovascular Diseases Antibodies  >1 publications with ATG4C and Cardiovascular Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with ATG4C and Abnormalities, Drug-Induced
 Necrosis Antibodies  >1 publications with ATG4C and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with ATG4C and Lung
 Liver Antibodies  >1 publications with ATG4C and Liver
 Mammary Gland Antibodies  >1 publications with ATG4C and Mammary Gland
 Placenta Antibodies  >1 publications with ATG4C and Placenta
 Kidney Antibodies  >1 publications with ATG4C and Kidney
 Uterus Antibodies  >1 publications with ATG4C and Uterus
 Vascular Antibodies  >1 publications with ATG4C and Vascular
 Brain Antibodies  >1 publications with ATG4C and Brain
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