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anti-ATG5 antibody :: Rabbit ATG5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150643
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATG5, Polyclonal Antibody

★Popular Item★
 Also Known As   

ATG5 Antibody

 Product Synonym Names    ATG5; ASP; APG5; APG5L; hAPG5; APG5-LIKE; ATG5 autophagy related 5 homolog (S. cerevisiae)
 Product Gene Name   

anti-ATG5 antibody

[Similar Products]
 Antibody/Peptide Pairs    ATG5 peptide (MBS153237) is used for blocking the activity of ATG5 antibody (MBS150643)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for A9UGY9
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.
 Purity/Purification    ATG5 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ATG5 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human ATG5.
 Buffer    ATG5 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ATG5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ATG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATG5 antibody

   ATG5 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.
 Applications Tested/Suitable for anti-ATG5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ATG5 antibody    ATG5 antibody can be used for the detection of ATG5 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ATG5 antibody    Western blot analysis of ATG5 in rat spleen tissue lysate with ATG5 antibody at (A) 1 and (B) 2 μg/mL.
anti-ATG5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ATG5 antibody    Immunohistochemistry of ATG5 in human spleen tissue with ATG5 antibody at 2.5 μg/mL.
anti-ATG5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ATG5 antibody    Immunofluorescence of ATG5 in Human Spleen cells with ATG5 antibody at 20 μg/mL.
anti-ATG5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ATG5. It may not necessarily be applicable to this product.
 NCBI GI #    119568800
 NCBI GeneID    9474
 NCBI Accession #    EAW48415 [Other Products]
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 UniProt Primary Accession #    A9UGY9 [Other Products]
 UniProt Related Accession #    Q9H1Y0 [Other Products]
 Molecular Weight    32,447 Da
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 NCBI Official Full Name    ATG5 autophagy related 5 homolog (S. cerevisiae), isoform CRA_b
 NCBI Official Synonym Full Names    autophagy related 5
 NCBI Official Symbol    ATG5 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; APG5; APG5L; hAPG5; APG5-LIKE
[Similar Products]
 NCBI Protein Information    autophagy protein 5; apoptosis-specific protein; ATG5 autophagy related 5 homolog
 UniProt Protein Name    Autophagy protein 5
 Protein Family    Autophagy protein
 UniProt Gene Name    ATG5 [Similar Products]
 UniProt Entry Name    A9UGY9_HUMAN
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 UniProt Comments for ATG5    ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Apoptosis; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme

Molecular Function: protein binding; APG8 conjugating enzyme activity

Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; C-terminal protein lipidation; post-translational protein modification; vasodilation; regulation of release of sequestered calcium ion into cytosol; cellular response to nitrogen starvation; heart contraction; regulation of cytokine secretion during immune response; mitochondrion degradation; innate immune response; autophagy; negative regulation of protein ubiquitination; blood vessel remodeling; negative regulation of interferon type I production; otolith development; negative regulation of apoptosis; autophagic vacuole formation
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 Research Articles on ATG5    1. Genetic variation in ATG5 is associated with increased susceptibility for thyroid carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ATG5 antibodyDiseases associated with anti-ATG5 antibody
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Shigellosis Pathway antibodies  Shigellosis Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >58 publications with ATG5 and Necrosis
 Cardiovascular Diseases Antibodies  >55 publications with ATG5 and Cardiovascular Diseases
 Inflammation Antibodies  >55 publications with ATG5 and Inflammation
 Disease Models, Animal Antibodies  >47 publications with ATG5 and Disease Models, Animal
 Liver Diseases Antibodies  >42 publications with ATG5 and Liver Diseases
 Gastrointestinal Diseases Antibodies  >35 publications with ATG5 and Gastrointestinal Diseases
 Heart Diseases Antibodies  >34 publications with ATG5 and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >27 publications with ATG5 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >25 publications with ATG5 and Breast Neoplasms
 Liver Neoplasms Antibodies  >24 publications with ATG5 and Liver Neoplasms
Organs/Tissues associated with anti-ATG5 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >93 publications with ATG5 and Blood
 Brain Antibodies  >89 publications with ATG5 and Brain
 Liver Antibodies  >69 publications with ATG5 and Liver
 Muscle Antibodies  >59 publications with ATG5 and Muscle
 Lung Antibodies  >58 publications with ATG5 and Lung
 Heart Antibodies  >52 publications with ATG5 and Heart
 Kidney Antibodies  >35 publications with ATG5 and Kidney
 Eye Antibodies  >31 publications with ATG5 and Eye
 Bone Antibodies  >31 publications with ATG5 and Bone
 Prostate Antibodies  >25 publications with ATG5 and Prostate
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