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anti-Serpinc1 antibody :: Sheep ATIII - Antithrombin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512015 anti-Serpinc1 antibody
Unit / Price
10 mg  /  $210 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATIII - Antithrombin (Serpinc1), Polyclonal Antibody

 Also Known As   

Sheep anti-human Antithrombin (ATIII), Whole IgG from antiserum

 Product Synonym Names    ATIII - Antithrombin, human
 Product Gene Name   

anti-Serpinc1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000067.5 (162908737..162933146). Location: 1 H2.1; 1 84.6 cM
 3D Structure    ModBase 3D Structure for P32261
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 Clonality    Polyclonal
 Host    Sheep
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 Specificity    This antibody is specific for antithrombin as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Purified IgG.
Vial containing ml of whole IgG representing approximately 1 ml of antiserum. Total protein is 10 mg.
 Form/Format    Whole IgG, clear liquid.
 Concentration    IgG concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 13.4. (lot specific)
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 Immunogen    Human antithrombin purified from plasma.
 Buffer    10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol.
 Neutralizing Activity    Not determined
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 Preparation and Storage    Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.
 Other Notes    Small volumes of anti-Serpinc1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Serpinc1 antibody

   Antithrombin, also known as Antithrombin III (ATIII), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of thrombin in plasma. It is produced in the liver and circulates in plasma at ~200 ug/ml (~3.5 uM). Antithrombin inhibits a broad spectrum of serine proteases including thrombin, activated forms of factor X, factor IX, factor XI, factor XII, as well as kallikrein, plasmin and urokinase. Enzyme inhibition by antithrombin occurs through proteolytic cleavage at Arg385-Ser386 and subsequent rapid formation of a stable, inactive 1:1 enzyme-antithrombin complex. Heparin has a profound accelerating effect on the inhibitory activity of antithrombin towards some enzymes. For example, the rate of inhibition of thrombin and activated factor X is increased 1000-fold in the presence of optimal concentrations of heparin, whereas heparin has relatively little effect on the inhibition rate of activated factor XI, activated factor XII and kallikrein. Antithrombin is a single chain molecule with a molecular weight of 59 kDa. Interaction with thrombin results in an SDS-stable thrombin-antithrombin complex of 96 kDa1-3.
 Application Notes for anti-Serpinc1 antibody    Suitable as a source of antibodies to human antithrombin.
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NCBI/Uniprot data below describe general gene information for Serpinc1. It may not necessarily be applicable to this product.
 NCBI GI #    258959
 NCBI GeneID    11905
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 UniProt Primary Accession #    P32261 [Other Products]
 UniProt Related Accession #    P32261; Q543J5 [Other Products]
 Molecular Weight    52,004 Da [Similar Products]
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 NCBI Official Full Name    antithrombin III
 NCBI Official Synonym Full Names    serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
 NCBI Official Symbol    Serpinc1 [Similar Products]
 NCBI Official Synonym Symbols   
At3; At-3; ATIII; AI114908
[Similar Products]
 NCBI Protein Information    antithrombin-III; serpin C1; anti-thrombin 3; serpin peptidase inhibitor, clade C, member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
 UniProt Protein Name    Antithrombin-III
 UniProt Synonym Protein Names   
Serpin C1
 Protein Family    Antithrombin
 UniProt Gene Name    Serpinc1 [Similar Products]
 UniProt Synonym Gene Names    At3 [Similar Products]
 UniProt Entry Name    ANT3_MOUSE
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 UniProt Comments for Serpinc1    Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Plasma.

Post-translational modification: Phosphorylation sites are present in the extracelllular medium

Sequence similarities: Belongs to the serpin family.
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Product References and Citations for anti-Serpinc1 antibody

   1. Damus PS, Rosenberg RD; Antithrombin - Heparin Cofactor; Methods in Enzymology 45, pp 653-669, 1976.
2. Harpel PC; Blood Proteolytic Enzyme Inhibitors: Their Role in Modulating Blood Coagulation and Fibrinolytic Enzyme Pathways; in Hemostasis and Thrombosis, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 738- 747, J.B. Lippincott Co., Philadelphia PA, USA, 1982.
3. Griffith MJ, Noyes CM, Church FC; Reactive Site Peptide Structural Similarity between Heparin Cofactor II and Antithrombin III; JBC:260, pp 2218-2225, 1985.
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 Research Articles on Serpinc1    1. Mice homozygous for the heparin-binding domain mutation R48C developed spontaneous, life-threatening thrombosis, occurring as early as the day of birth. Only 60% of the offspring reached weaning age, with further loss at different ages
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Serpinc1 antibodyDiseases associated with anti-Serpinc1 antibody
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Thrombophilia Antibodies  >14 publications with Serpinc1 and Thrombophilia
 Antithrombin III Deficiency Antibodies  >12 publications with Serpinc1 and Antithrombin III Deficiency
 Vascular Diseases Antibodies  >11 publications with Serpinc1 and Vascular Diseases
 Thrombosis Antibodies  >10 publications with Serpinc1 and Thrombosis
 Venous Thrombosis Antibodies  >7 publications with Serpinc1 and Venous Thrombosis
 Lung Diseases Antibodies  >2 publications with Serpinc1 and Lung Diseases
 Liver Neoplasms Antibodies  >2 publications with Serpinc1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >2 publications with Serpinc1 and Adenocarcinoma
 Hypertension Antibodies  >2 publications with Serpinc1 and Hypertension
 Neoplasms Antibodies  >2 publications with Serpinc1 and Neoplasms
Organs/Tissues associated with anti-Serpinc1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with Serpinc1 and Liver
 Muscle Antibodies  >2 publications with Serpinc1 and Muscle
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