Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ATM rightarrow Polyclonal ATM  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MEF2D Antibody
 • Horse IgG (Fab) Immunoglobulin
 • tumor necrosis factor, alpha-induced protein 6 Antibody
 • yellow fever virus (YFV) antibody (IgM) ELISA Kit
 • Hepatitis C Virus (HCV) Core Antigen Antibody
 • 15-PGDH - HPGD Antibody
 • CLDN9 (Claudin 9) CLIA Kit
 • CD80 Antibody
 • Colipase (CLPS) ELISA Kit
 • A kinase (PRKA) anchor protein 12 (AKAP12) ELISA Kit
 • beta2 Microglobulin (beta2-MG) ELISA Kit
 • A ProlifeRation inducing ligand (APRIL) ELISA Kit
 • Annexin A5 (ANXA5) Recombinant Protein
 • anti-Mouse Kappa Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ATM antibody :: Rabbit ATM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222389 anti-ATM antibody
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATM, Polyclonal Antibody

 Also Known As   

RABBIT ANTI ATM (aa1-308)

 Product Gene Name   

anti-ATM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    208900
 3D Structure    ModBase 3D Structure for Q13315
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Hamster, Monkey, Mouse
Section Bar
 Specificity    This item recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia. ATM protein is expressed within the nucleus of all normal cells, and is thought to be important in detection of DNA damage.
 Form/Format    Serum
Serum - liquid
Section Bar
 Perservative Stabilisers    0.09% Sodium Azide
 Immunogen    Recombinant human ATM fragment (amino acids 1-308).
 Antiserum Preparation    Antisera to ATM were raised by repeated immunisation of rabbits with highly purified antigen.
 Target Species    Human
Section Bar
 Preparation and Storage    Store at 4 degree C for one month or at -20 degree C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-ATM antibody

   MBS222389 recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia. ATM protein is expressed within the nucleus of all normal cells, and is thought to be important in detection of DNA damage.
 Applications Tested/Suitable for anti-ATM antibody   

Western Blot (WB)

 Application Notes for anti-ATM antibody    Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/200
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
 NCBI GI #    71902540
 NCBI GeneID    472
 NCBI Accession #    NP_000042.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000051.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q13315 [Other Products]
 UniProt Secondary Accession #    O15429; Q12758; Q16551; Q93007; Q9NP02; Q9UCX7; B2RNX5 [Other Products]
 UniProt Related Accession #    Q13315 [Other Products]
 Molecular Weight    350,687 Da
Table BarTOPTable Bar
 NCBI Official Full Name    serine-protein kinase ATM
 NCBI Official Synonym Full Names    ATM serine/threonine kinase
 NCBI Official Symbol    ATM [Similar Products]
 NCBI Official Synonym Symbols   
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
[Similar Products]
 NCBI Protein Information    serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated
 UniProt Protein Name    Serine-protein kinase ATM
 UniProt Synonym Protein Names   
Ataxia telangiectasia mutated; A-T mutated
 Protein Family    ATM interactor
 UniProt Gene Name    ATM [Similar Products]
 UniProt Synonym Gene Names    A-T mutated [Similar Products]
 UniProt Entry Name    ATM_HUMAN
Section Bar
 NCBI Summary for ATM    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Section Bar
 UniProt Comments for ATM    ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: EC 2.7.11.1; Tumor suppressor; Protein kinase, atypical; Kinase, protein; DNA repair, damage; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; PIKK family

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasmic membrane-bound vesicle; spindle

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; 1-phosphatidylinositol-3-kinase activity; protein complex binding; protein N-terminus binding; DNA-dependent protein kinase activity; histone serine kinase activity; ATP binding

Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; positive regulation of apoptosis; heart development; protein amino acid autophosphorylation; pre-B cell allelic exclusion; negative regulation of B cell proliferation; signal transduction; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of neuron apoptosis; double-strand break repair; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; DNA repair; double-strand break repair via homologous recombination; neuron apoptosis; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; meiotic recombination; response to hypoxia; response to ionizing radiation; brain development; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to DNA damage stimulus; oocyte development

Disease: Ataxia-telangiectasia; Breast Cancer
Table BarTOPTable Bar
 Research Articles on ATM    1. These results indicate that ATM regulates a sub-set of NF-kappaB dependent genes after a genotoxic stress by direct phosphorylation of p65.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ATM antibodyPathways associated with anti-ATM antibody
 Reference Product  PubMed Publications
 BRCA1 antibody  >555 publications with ATM and BRCA1
 CHEK2 antibody  >473 publications with ATM and CHEK2
 TP53 antibody  >390 publications with ATM and TP53
 H2AFX antibody  >369 publications with ATM and H2AFX
 MRE11A antibody  >187 publications with ATM and MRE11A
 TP53BP1 antibody  >114 publications with ATM and TP53BP1
 RAD17 antibody  >63 publications with ATM and RAD17
 KAT5 antibody  >23 publications with ATM and KAT5
 CHEK1 antibody  >20 publications with ATM and CHEK1
 ABL1 antibody  >4 publications with ATM and ABL1
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-ATM antibodyOrgans/Tissues associated with anti-ATM antibody
 Disease Name  Pubmed Publications
 Ataxia Telangiectasia Antibodies  >4255 publications with ATM and Ataxia Telangiectasia
 Nervous System Diseases Antibodies  >1512 publications with ATM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1303 publications with ATM and Cardiovascular Diseases
 Brain Diseases Antibodies  >1294 publications with ATM and Brain Diseases
 Breast Neoplasms Antibodies  >478 publications with ATM and Breast Neoplasms
 Disease Models, Animal Antibodies  >312 publications with ATM and Disease Models, Animal
 Heart Diseases Antibodies  >301 publications with ATM and Heart Diseases
 Lung Diseases Antibodies  >233 publications with ATM and Lung Diseases
 Inflammation Antibodies  >214 publications with ATM and Inflammation
 Adenocarcinoma Antibodies  >194 publications with ATM and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1376 publications with ATM and Blood
 Brain Antibodies  >765 publications with ATM and Brain
 Lung Antibodies  >533 publications with ATM and Lung
 Vascular Antibodies  >516 publications with ATM and Vascular
 Heart Antibodies  >314 publications with ATM and Heart
 Muscle Antibodies  >247 publications with ATM and Muscle
 Liver Antibodies  >207 publications with ATM and Liver
 Skin Antibodies  >202 publications with ATM and Skin
 Kidney Antibodies  >175 publications with ATM and Kidney
 Nerve Antibodies  >165 publications with ATM and Nerve
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions