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anti-KCNJ10 antibody :: Rabbit anti-Human ATP-sensitive inward rectifier potassium channel 10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496426
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-sensitive inward rectifier potassium channel 10 (KCNJ10), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human ATP-sensitive inward rectifier potassium channel 10 polyclonal Antibody

 Product Synonym Names    ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel; inwardly rectifying subfamily J member 10; KCNJ10
 Product Gene Name   

anti-KCNJ10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602208
 3D Structure    ModBase 3D Structure for P78508
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human ATP-sensitive inward rectifier potassium channel 10 protein(165-379aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23637
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KCNJ10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KCNJ10 antibody

   May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
 Applications Tested/Suitable for anti-KCNJ10 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-KCNJ10 antibody    Immunohistochemistry of paraffin-embedded human epityphlon tissue using MBS1496426 at dilution 1:100
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KCNJ10 antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS1496426 at dilution 1:100
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KCNJ10 antibody    Immunofluorescent analysis of Hela cells using MBS1496426 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KCNJ10. It may not necessarily be applicable to this product.
 NCBI GI #    25121966
 NCBI GeneID    3766
 NCBI Accession #    NP_002232.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002241.4 [Other Products]
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 UniProt Primary Accession #    P78508 [Other Products]
 UniProt Secondary Accession #    Q5VUT9; Q8N4I7; Q92808; A3KME7 [Other Products]
 UniProt Related Accession #    P78508 [Other Products]
 Molecular Weight    42,508 Da [Similar Products]
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 10
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily J member 10
 NCBI Official Symbol    KCNJ10 [Similar Products]
 NCBI Official Synonym Symbols   
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 10
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 10
 UniProt Synonym Protein Names   
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ10 [Similar Products]
 UniProt Entry Name    KCJ10_HUMAN
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 NCBI Summary for KCNJ10    This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNJ10    Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, potassium

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATP binding; ATP-activated inward rectifier potassium channel activity; protein binding

Biological Process: adult walking behavior; glutamate uptake during transmission of nerve impulse; myelination in the central nervous system; potassium ion homeostasis; potassium ion import; potassium ion transport; regulation of long-term neuronal synaptic plasticity; regulation of resting membrane potential; synaptic transmission; visual perception

Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
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 Research Articles on KCNJ10    1. anti-KIR4.1 antibody levels differed in multiple sclerosis patients during relapse and remission; as such, they may represent a marker of disease exacerbation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNJ10 antibodyPathways associated with anti-KCNJ10 antibody
 Reference Product  PubMed Publications
 AQP4 antibody  >47 publications with KCNJ10 and AQP4
 FOXI1 antibody  >13 publications with KCNJ10 and FOXI1
 KCNJ16 antibody  >8 publications with KCNJ10 and KCNJ16
 MLC1 antibody  >1 publications with KCNJ10 and MLC1
 CAV1 antibody  >1 publications with KCNJ10 and CAV1
 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with anti-KCNJ10 antibodyOrgans/Tissues associated with anti-KCNJ10 antibody
 Disease Name  Pubmed Publications
 Edema Antibodies  >19 publications with KCNJ10 and Edema
 Neurobehavioral Manifestations Antibodies  >17 publications with KCNJ10 and Neurobehavioral Manifestations
 SeSAME syndrome Antibodies  >13 publications with KCNJ10 and SeSAME syndrome
 Multiple Sclerosis Antibodies  >13 publications with KCNJ10 and Multiple Sclerosis
 Kidney Diseases Antibodies  >11 publications with KCNJ10 and Kidney Diseases
 Inflammation Antibodies  >8 publications with KCNJ10 and Inflammation
 Hypertension Antibodies  >7 publications with KCNJ10 and Hypertension
 Hypertrophy Antibodies  >7 publications with KCNJ10 and Hypertrophy
 Abnormalities, Multiple Antibodies  >5 publications with KCNJ10 and Abnormalities, Multiple
 Cognition Disorders Antibodies  >3 publications with KCNJ10 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >106 publications with KCNJ10 and Brain
 Eye Antibodies  >56 publications with KCNJ10 and Eye
 Ear Antibodies  >46 publications with KCNJ10 and Ear
 Kidney Antibodies  >43 publications with KCNJ10 and Kidney
 Blood Antibodies  >40 publications with KCNJ10 and Blood
 Nerve Antibodies  >31 publications with KCNJ10 and Nerve
 Ganglia Antibodies  >9 publications with KCNJ10 and Ganglia
 Spleen Antibodies  >1 publications with KCNJ10 and Spleen
 Adrenal Gland Antibodies  >1 publications with KCNJ10 and Adrenal Gland
 Embryonic Tissue Antibodies  >1 publications with KCNJ10 and Embryonic Tissue
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