NP_001688.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,277 Da
NCBI Official Full Name
ATP synthase subunit O, mitochondrial
NCBI Official Synonym Full Names
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
NCBI Protein Information
ATP synthase subunit O, mitochondrial
UniProt Protein Name
ATP synthase subunit O, mitochondrial
UniProt Synonym Protein Names
Oligomycin sensitivity conferral protein; OSCP
UniProt Synonym Gene Names
UniProt Entry Name
ATPO_HUMAN
NCBI Summary for ATP5O
The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP5O
ATP5O: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase delta chain family.
Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 3.6.3.14; Hydrolase
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleus; plasma membrane
Molecular Function: ATPase activity; drug binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; protein binding; transmembrane transporter activity; transporter activity
Biological Process: ATP biosynthetic process; cellular metabolic process; mitochondrial ATP synthesis coupled proton transport; proton transport
Research Articles on ATP5O
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Products associated with anti-ATP5O antibody
Pathways associated with anti-ATP5O antibody
Diseases associated with anti-ATP5O antibody
Organs/Tissues associated with anti-ATP5O antibody
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