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anti-ATP12A antibody :: Rabbit anti-Human ATP12A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211397
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP12A, Polyclonal Antibody

★Popular Item★
 Also Known As   

ATP12A Antibody (Center)

 Product Synonym Names    Potassium-transporting ATPase alpha chain 2; Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump; ATP12A; ATP1AL1
 Product Gene Name   

anti-ATP12A antibody

[Similar Products]
 Antibody/Peptide Pairs    ATP12A peptide (MBS9227789) is used for blocking the activity of ATP12A antibody (MBS9211397)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    833-859
 OMIM    182360
 3D Structure    ModBase 3D Structure for P54707
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This ATP12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 833-859 amino acids from the Central region of human ATP12A.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Precautions    ATP12A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
 Cellular Location    Membrane; Multi-pass membrane protein.
 Tissue Location    Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level)
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ATP12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATP12A antibody

   ATP12A belongs to the family of P-type cation transport ATPases. This protein is a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.
 Product Categories/Family for anti-ATP12A antibody    Signal Transduction
 Applications Tested/Suitable for anti-ATP12A antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS)

 Application Notes for anti-ATP12A antibody    WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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 Western Blot (WB) of anti-ATP12A antibody    Western blot analysis of ATP12A Antibody (Center) in K562 cell line lysates (35ug/lane). ATP12A (arrow) was detected using the purified Pab.
anti-ATP12A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ATP12A antibody    Formalin-fixed and paraffin-embedded human skin reacted with ATP12A Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-ATP12A antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-ATP12A antibody    ATP12A Antibody (Center) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ATP12A antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for ATP12A. It may not necessarily be applicable to this product.
 NCBI GI #    297374799
 NCBI GeneID    479
 NCBI Accession #    NP_001172014.1 [Other Products]
 NCBI Related Accession #    NP_001667.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_001185085.1 [Other Products]
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 UniProt Primary Accession #    P54707 [Other Products]
 UniProt Secondary Accession #    Q13816; Q13817; Q16734; Q5W035; Q8N5U2 [Other Products]
 UniProt Related Accession #    P54707 [Other Products]
 Molecular Weight    115511
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 NCBI Official Full Name    potassium-transporting ATPase alpha chain 2 isoform 1
 NCBI Official Synonym Full Names    ATPase, H+/K+ transporting, nongastric, alpha polypeptide
 NCBI Official Symbol    ATP12A [Similar Products]
 NCBI Official Synonym Symbols   
ATP1AL1
[Similar Products]
 NCBI Protein Information    potassium-transporting ATPase alpha chain 2
 UniProt Protein Name    Potassium-transporting ATPase alpha chain 2
 UniProt Synonym Protein Names   
Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump
 Protein Family    Potassium-transporting ATPase
 UniProt Gene Name    ATP12A [Similar Products]
 UniProt Synonym Gene Names    ATP1AL1 [Similar Products]
 UniProt Entry Name    AT12A_HUMAN
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 NCBI Summary for ATP12A    The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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 UniProt Comments for ATP12A    ATP12A: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Hydrolase; Transporter, ion channel; Energy Metabolism - oxidative phosphorylation; EC 3.6.3.10; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 13q12.12|13q12.1-q12.3

Cellular Component: hydrogen:potassium-exchanging ATPase complex; basolateral plasma membrane; plasma membrane

Molecular Function: metal ion binding; sodium:potassium-exchanging ATPase activity; hydrogen:potassium-exchanging ATPase activity; ATP binding

Biological Process: metabolic process; regulation of pH; potassium ion homeostasis; transmembrane transport; potassium ion transport
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Product References and Citations for anti-ATP12A antibody

   Li,J., et.al., Kidney Int. 65 (4), 1301-1310 (2004)
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 Research Articles on ATP12A    1. No significantly different expression levels could be detected in the various disease states compared to normal tissue.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATP12A antibodyPathways associated with anti-ATP12A antibody
 Reference Product  PubMed Publications
 ATP4A antibody  >1 publications with ATP12A and ATP4A
 ATP1B1 antibody  >1 publications with ATP12A and ATP1B1
 ATP4B antibody  >1 publications with ATP12A and ATP4B
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with anti-ATP12A antibodyOrgans/Tissues associated with anti-ATP12A antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >2 publications with ATP12A and Hypertension
 Heart Failure Antibodies  >1 publications with ATP12A and Heart Failure
 Neoplasms, Experimental Antibodies  >1 publications with ATP12A and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >1 publications with ATP12A and Prostatic Diseases
 Fetal Growth Retardation Antibodies  >1 publications with ATP12A and Fetal Growth Retardation
 Hyperplasia Antibodies  >1 publications with ATP12A and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with ATP12A and Pancreas
 Brain Antibodies  >1 publications with ATP12A and Brain
 Placenta Antibodies  >1 publications with ATP12A and Placenta
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