NP_001001323.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
130,617 Da
NCBI Official Full Name
plasma membrane calcium-transporting ATPase 1 isoform 1a
NCBI Official Synonym Full Names
ATPase plasma membrane Ca2+ transporting 1
NCBI Protein Information
plasma membrane calcium-transporting ATPase 1
UniProt Protein Name
Plasma membrane calcium-transporting ATPase 1
UniProt Synonym Protein Names
Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1
UniProt Synonym Gene Names
UniProt Entry Name
AT2B1_HUMAN
NCBI Summary for ATP2B1
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP2B1
PMCA1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.8; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 12q21.3
Cellular Component: integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane
Molecular Function: calcium-transporting ATPase activity; PDZ domain binding; protein binding
Biological Process: cellular calcium ion homeostasis; transport
Research Articles on ATP2B1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ATP2B1 antibody
Diseases associated with anti-ATP2B1 antibody
Organs/Tissues associated with anti-ATP2B1 antibody
|