CAG46749.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ATP6V0C
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
NCBI Official Synonym Symbols
ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L [Similar Products]
NCBI Protein Information
V-type proton ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar H+ ATPase proton channel subunit; vacuolar proton pump 16 kDa proteolipid subunit; vacuolar ATP synthase 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit
UniProt Protein Name
V-type proton ATPase 16 kDa proteolipid subunit
UniProt Synonym Protein Names
Vacuolar proton pump 16 kDa proteolipid subunit
UniProt Synonym Gene Names
UniProt Entry Name
VATL_HUMAN
NCBI Summary for ATP6V0C
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
UniProt Comments for ATP6V0C
ATP6V0C: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family.
Protein type: Transporter, iron; Transporter, ion channel; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: phagocytic vesicle membrane; focal adhesion; lysosomal membrane; integral to membrane; endosome membrane
Molecular Function: protein binding; ubiquitin protein ligase binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism
Biological Process: interaction with host; proton transport; viral reproduction; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport; positive regulation of Wnt receptor signaling pathway
Research Articles on ATP6V0C
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Products associated with anti-ATP6V0C antibody
Pathways associated with anti-ATP6V0C antibody
Diseases associated with anti-ATP6V0C antibody
Organs/Tissues associated with anti-ATP6V0C antibody
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