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anti-ATP6V0C antibody :: Rabbit ATP6V0C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9212545
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP6V0C, Polyclonal Antibody

★Popular Item★
 Also Known As   

ATP6V0C Antibody (C-term)

 Product Synonym Names    V-type proton ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit; Vacuolar proton pump 16 kDa proteolipid subunit; ATP6V0C; ATP6C; ATP6L; ATPL
 Product Gene Name   

anti-ATP6V0C antibody

[Similar Products]
 Antibody/Peptide Pairs    ATP6V0C peptide (MBS9217610) is used for blocking the activity of ATP6V0C antibody (MBS9212545)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    100-126
 OMIM    108745
 3D Structure    ModBase 3D Structure for P27449
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB24576
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: C Elegans, Bovine, Drosophila, Rat)
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 Specificity    This ATP6V0C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the C-terminal region of human ATP6V0C.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
 Celllar Location    Vacuole membrane; Multi-pass membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ATP6V0C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATP6V0C antibody

   ATP6V0C is a component of vacuolar ATPase
(V-ATPase), a multisubunit enzyme that mediates acidification of
eukaryotic intracellular organelles. V-ATPase dependent organelle
acidification is necessary for such intracellular processes as
protein sorting, zymogen activation, receptor-mediated endocytosis,
and synaptic vesicle proton gradient generation. V-ATPase is
composed of a cytosolic V1 domain and a transmembrane V0 domain.
The V1 domain consists of three A and three B subunits, two G
subunits plus the C, D, E, F, and H subunits. The V1 domain
contains the ATP catalytic site. The V0 domain consists of five
different subunits: a, c, c', c', and d. ATP6V0C encodes the V0
subunit c.
 Product Categories/Family for anti-ATP6V0C antibody    Signal Transduction
 Applications Tested/Suitable for anti-ATP6V0C antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ATP6V0C antibody    WB~~1:1000
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 Western Blot (WB) of anti-ATP6V0C antibody    ATP6V0C Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the ATP6V0C antibody detected the ATP6V0C protein (arrow).
anti-ATP6V0C antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ATP6V0C. It may not necessarily be applicable to this product.
 NCBI GI #    310832382
 NCBI GeneID    527
 NCBI Accession #    NP_001185498.1 [Other Products]
 NCBI Related Accession #    NP_001685.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198569.1 [Other Products]
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 UniProt Primary Accession #    P27449 [Other Products]
 UniProt Secondary Accession #    Q6FH26 [Other Products]
 UniProt Related Accession #    P27449 [Other Products]
 Molecular Weight    15736
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 NCBI Official Full Name    V-type proton ATPase 16 kDa proteolipid subunit
 NCBI Official Synonym Full Names    ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
 NCBI Official Symbol    ATP6V0C [Similar Products]
 NCBI Official Synonym Symbols   
ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L
[Similar Products]
 NCBI Protein Information    V-type proton ATPase 16 kDa proteolipid subunit
 UniProt Protein Name    V-type proton ATPase 16 kDa proteolipid subunit
 UniProt Synonym Protein Names   
Vacuolar proton pump 16 kDa proteolipid subunit
 UniProt Gene Name    ATP6V0C [Similar Products]
 UniProt Synonym Gene Names    ATP6C; ATP6L; ATPL; V-ATPase 16 kDa proteolipid subunit [Similar Products]
 UniProt Entry Name    VATL_HUMAN
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 NCBI Summary for ATP6V0C    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
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 UniProt Comments for ATP6V0C    ATP6V0C: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family.

Protein type: Transporter, iron; Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: phagocytic vesicle membrane; focal adhesion; lysosomal membrane; integral to membrane; endosome membrane

Molecular Function: protein binding; ubiquitin protein ligase binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism

Biological Process: interaction with host; proton transport; viral reproduction; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport; positive regulation of Wnt receptor signaling pathway
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Product References and Citations for anti-ATP6V0C antibody

   O'Callaghan, K.M., et al. J. Biol. Chem. 285(1):381-391(2010)
You, H., et al. Cancer Lett. 280(1):110-119(2009)
Lee, I., et al. J. Biol. Chem. 279(51):53007-53014(2004)
Morel, N. Biol. Cell 95(7):453-457(2003)
Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)
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 Research Articles on ATP6V0C    1. The consequences of pharmacological inhibition of v-ATPase (by concanamycin) on proliferation, migration, VEGF-receptor 2 (VEGFR2) trafficking and signaling, as well as Notch-mediated transcription in endothelial cells, were examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATP6V0C antibodyPathways associated with anti-ATP6V0C antibody
 Reference Product  PubMed Publications
 ATP6V0A2 antibody  >1 publications with ATP6V0C and ATP6V0A2
 TCIRG1 antibody  >1 publications with ATP6V0C and TCIRG1
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Diseases associated with anti-ATP6V0C antibodyOrgans/Tissues associated with anti-ATP6V0C antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with ATP6V0C and Breast Neoplasms
 Nervous System Diseases Antibodies  >2 publications with ATP6V0C and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with ATP6V0C and Disease Models, Animal
 Mood Disorders Antibodies  >1 publications with ATP6V0C and Mood Disorders
 Mental Disorders Antibodies  >1 publications with ATP6V0C and Mental Disorders
 Neoplasms, Experimental Antibodies  >1 publications with ATP6V0C and Neoplasms, Experimental
 Brain Diseases Antibodies  >1 publications with ATP6V0C and Brain Diseases
 Depressive Disorder Antibodies  >1 publications with ATP6V0C and Depressive Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ATP6V0C and Brain
 Nerve Antibodies  >2 publications with ATP6V0C and Nerve
 Eye Antibodies  >2 publications with ATP6V0C and Eye
 Liver Antibodies  >1 publications with ATP6V0C and Liver
 Connective Tissue Antibodies  >1 publications with ATP6V0C and Connective Tissue
 Bone Antibodies  >1 publications with ATP6V0C and Bone
 Blood Antibodies  >1 publications with ATP6V0C and Blood
 Embryonic Tissue Antibodies  >1 publications with ATP6V0C and Embryonic Tissue
 Prostate Antibodies  >1 publications with ATP6V0C and Prostate
 Lung Antibodies  >1 publications with ATP6V0C and Lung
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