P36543
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
V-type proton ATPase subunit e 1
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
NCBI Official Synonym Symbols
M9.2; ATP6H; Vma21; Vma21p; ATP6V0E [Similar Products]
NCBI Protein Information
V-type proton ATPase subunit e 1; V-ATPase H subunit; V-ATPase subunit e 1; V-ATPase M9.2 subunit; vacuolar proton pump H subunit; vacuolar ATP synthase subunit H; vacuolar proton pump subunit e 1; vacuolar proton-ATPase subunit M9.2; V-ATPase 9.2 kDa membrane accessory protein; H(+)-transporting two-sector ATPase, subunit H
UniProt Protein Name
V-type proton ATPase subunit e 1
UniProt Synonym Protein Names
V-ATPase 9.2 kDa membrane accessory protein; V-ATPase M9.2 subunit; Vacuolar proton pump subunit e 1
UniProt Synonym Gene Names
UniProt Entry Name
VA0E1_HUMAN
NCBI Summary for ATP6V1E1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V1E1
ATP6V0E1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase e1/e2 subunit family.
Protein type: Transporter, ion channel; Membrane protein, integral; Transporter, iron; Transporter; Hydrolase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: phagocytic vesicle membrane; membrane; integral to membrane; endosome membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of ions; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism
Biological Process: interaction with host; vacuolar acidification; proton transport; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; response to amino acid stimulus; cell growth; transmembrane transport
Research Articles on ATP6V1E1
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Pathways associated with anti-ATP6V1E1 antibody
Diseases associated with anti-ATP6V1E1 antibody
Organs/Tissues associated with anti-ATP6V1E1 antibody
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