EAW93003.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1, isoform CRA_a
NCBI Official Synonym Full Names
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
NCBI Protein Information
phospholipid-transporting ATPase IA; ATPase II; chromaffin granule ATPase II; aminophospholipid translocase; ATPase class I type 8A member 1; probable phospholipid-transporting ATPase IA; P4-ATPase flippase complex alpha subunit ATP8A1
UniProt Protein Name
Phospholipid-transporting ATPase IA
UniProt Synonym Protein Names
ATPase class I type 8A member 1; Chromaffin granule ATPase II; P4-ATPase flippase complex alpha subunit ATP8A1
UniProt Synonym Gene Names
UniProt Entry Name
AT8A1_HUMAN
NCBI Summary for ATP8A1
The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP8A1
ATP8A1: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Transporter, ion channel; Transporter; EC 3.6.3.1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p13
Cellular Component: Golgi apparatus; membrane; endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: phospholipid-translocating ATPase activity; protein binding; magnesium ion binding; ATP binding; cation-transporting ATPase activity
Biological Process: phospholipid translocation; metabolic process; learning; transmembrane transport; cation transport; positive regulation of cell migration
Research Articles on ATP8A1
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Pathways associated with anti-ATP8A1 antibody
Diseases associated with anti-ATP8A1 antibody
Organs/Tissues associated with anti-ATP8A1 antibody
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