NP_001175.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 300 kDa Predicted: 302 kDa
NCBI Official Full Name
serine/threonine-protein kinase ATR isoform 1
NCBI Official Synonym Full Names
ATR serine/threonine kinase
NCBI Protein Information
serine/threonine-protein kinase ATR
UniProt Protein Name
Serine/threonine-protein kinase ATR
UniProt Synonym Protein Names
Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1
UniProt Synonym Gene Names
NCBI Summary for ATR
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
UniProt Comments for ATR
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
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Products associated with anti-ATR antibody
Pathways associated with anti-ATR antibody
Diseases associated with anti-ATR antibody
Organs/Tissues associated with anti-ATR antibody
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