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anti-AURKB antibody :: Rabbit anti-Human AURKB / Aurora-B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241362
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AURKB / Aurora-B, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human AURKB / Aurora-B

 Product Synonym Names    Anti-AURKB / Aurora-B Antibody (aa227-238) IHC-plus; AURKB; AIRK2; AIK2; Aurora kinase B; Aurora kinase B-Sv1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; ARK-2; ARK2; Aurkb-sv1; Aurkb-sv2; Aurora 1; Aurora-B; AIM-1; IPL1; STK-1; STK5; PPP1R48; AurB; Aurora B; Aurora kinase B-Sv2; Aurora-1; Human AURKB; Aurora-B
 Product Gene Name   

anti-AURKB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604970
 3D Structure    ModBase 3D Structure for Q96GD4
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    aa 227-238 of Human Aurora Kinase B protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human AURKB / Aurora-B.
 Immunogen Type    Synthetic peptide
 Immunogen    AURKB / Aurora-B antibody was raised against synthetic peptide from human AURKB / Aurora-B.
 Antigen Modification    aa227-238
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-AURKB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AURKB antibody

   ARK2, an Aurora/IPL1-like protein kinase, functions in bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics, and chromosome condensation and cohesion. ARK2 has been shown to be physically associated with inner centromere protein (INCENP) during mitosis, and activated ARK2 has been shown to phosphorylate histone H3.
 Product Categories/Family for anti-AURKB antibody    Family: Protein Kinase
Subfamily: Aurora/IPL1-like
 Applications Tested/Suitable for anti-AURKB antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-AURKB antibody    ELISA (1:5000 - 1:20000), IF, IHC-P (5 ug/ml), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-AURKB antibody    Anti-AURKB / Aurora-B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-AURKB antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AURKB antibody    Anti-AURKB / Aurora-B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-AURKB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AURKB. It may not necessarily be applicable to this product.
 NCBI GI #    83776600
 NCBI GeneID    9212
 NCBI Accession #    NP_004208.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004217.3 [Other Products]
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 UniProt Primary Accession #    Q96GD4 [Other Products]
 UniProt Secondary Accession #    O14630; O60446; O95083; Q96DV5; Q9UQ46; B4DNM4; C7G533; C7G534; C7G535; D3DTR4; J9JID1 [Other Products]
 UniProt Related Accession #    Q96GD4 [Other Products]
 Molecular Weight    39,467 Da
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 NCBI Official Full Name    aurora kinase B isoform 1
 NCBI Official Synonym Full Names    aurora kinase B
 NCBI Official Symbol    AURKB [Similar Products]
 NCBI Official Synonym Symbols   
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
[Similar Products]
 NCBI Protein Information    aurora kinase B; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1
 UniProt Protein Name    Aurora kinase B
 UniProt Synonym Protein Names   
Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B
 Protein Family    Aurora kinase
 UniProt Gene Name    AURKB [Similar Products]
 UniProt Synonym Gene Names    AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2 [Similar Products]
 UniProt Entry Name    AURKB_HUMAN
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 NCBI Summary for AURKB    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
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 UniProt Comments for AURKB    AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; AUR family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: spindle microtubule; spindle; spindle pole centrosome; midbody; spindle midzone; nucleus; cytosol; condensed nuclear chromosome, pericentric region; chromocenter

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding

Biological Process: positive regulation of cytokinesis; spindle stabilization; spindle checkpoint; spindle midzone assembly involved in mitosis; protein amino acid autophosphorylation; regulation of chromosome segregation; negative regulation of transcription from RNA polymerase II promoter; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation; negative regulation of cytokinesis; cell proliferation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; histone modification; abscission; mitotic cell cycle; negative regulation of protein binding; negative regulation of B cell apoptosis; aging
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 Research Articles on AURKB    1. High expression of aurora kinase B is associated with mantle cell lymphoma harboring Burkitt's-like translocations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AURKB antibodyPathways associated with anti-AURKB antibody
 Reference Product  PubMed Publications
 INCENP antibody  >91 publications with AURKB and INCENP
 BIRC5 antibody  >82 publications with AURKB and BIRC5
 NDC80 antibody  >23 publications with AURKB and NDC80
 CDCA8 antibody  >23 publications with AURKB and CDCA8
 CDC20 antibody  >12 publications with AURKB and CDC20
 BUB1B antibody  >10 publications with AURKB and BUB1B
 KIF23 antibody  >9 publications with AURKB and KIF23
 KIF20A antibody  >4 publications with AURKB and KIF20A
 CENPA antibody  >4 publications with AURKB and CENPA
 RACGAP1 antibody  >1 publications with AURKB and RACGAP1
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
Diseases associated with anti-AURKB antibodyOrgans/Tissues associated with anti-AURKB antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >29 publications with AURKB and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >28 publications with AURKB and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >21 publications with AURKB and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >20 publications with AURKB and Lung Neoplasms
 Nervous System Diseases Antibodies  >18 publications with AURKB and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >15 publications with AURKB and Neoplasm Metastasis
 Pancreatic Neoplasms Antibodies  >13 publications with AURKB and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >13 publications with AURKB and Disease Models, Animal
 Liver Neoplasms Antibodies  >11 publications with AURKB and Liver Neoplasms
 Prostatic Neoplasms Antibodies  >11 publications with AURKB and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with AURKB and Blood
 Lung Antibodies  >26 publications with AURKB and Lung
 Liver Antibodies  >21 publications with AURKB and Liver
 Brain Antibodies  >20 publications with AURKB and Brain
 Prostate Antibodies  >17 publications with AURKB and Prostate
 Bone Antibodies  >15 publications with AURKB and Bone
 Bone Marrow Antibodies  >12 publications with AURKB and Bone Marrow
 Testis Antibodies  >11 publications with AURKB and Testis
 Lymph Antibodies  >11 publications with AURKB and Lymph
 Lymph Node Antibodies  >11 publications with AURKB and Lymph Node
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