NP_000045.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
vasopressin V2 receptor isoform 1
NCBI Official Synonym Full Names
arginine vasopressin receptor 2
NCBI Protein Information
vasopressin V2 receptor
UniProt Protein Name
Vasopressin V2 receptor
UniProt Synonym Protein Names
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
UniProt Synonym Gene Names
NCBI Summary for AVPR V2
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
UniProt Comments for AVPR V2
AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: clathrin-coated vesicle membrane; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function: peptide binding; protein binding; vasopressin receptor activity
Biological Process: adenylate cyclase activation; cellular response to hormone stimulus; excretion; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; hemostasis; I-kappaB kinase/NF-kappaB signaling; interferon-gamma production; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of protein ubiquitination; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; renal water homeostasis; response to cytokine; response to peptide; telencephalon development
Disease: Diabetes Insipidus, Nephrogenic, X-linked; Nephrogenic Syndrome Of Inappropriate Antidiuresis
Research Articles on AVPR V2
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Products associated with anti-AVPR V2 antibody
Pathways associated with anti-AVPR V2 antibody
Diseases associated with anti-AVPR V2 antibody
Organs/Tissues associated with anti-AVPR V2 antibody
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