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anti-AVPR2 antibody :: Rabbit anti-Human AVPR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203842
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AVPR2, Polyclonal Antibody

 Also Known As   

AVPR2 Antibody (C-term)

 Product Synonym Names    Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; AVPR2; ADHR; DIR; DIR3; V2R
 Product Gene Name   

anti-AVPR2 antibody

[Similar Products]
 Antibody/Peptide Pairs    AVPR2 peptide (MBS9229812) is used for blocking the activity of AVPR2 antibody (MBS9203842)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300538
 3D Structure    ModBase 3D Structure for P30518
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This AVPR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-377 amino acids from the C-terminal region of human AVPR2.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Crown Antibody    Yes
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-AVPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AVPR2 antibody

   Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
 Product Categories/Family for anti-AVPR2 antibody    Crown Antibodies
 Applications Tested/Suitable for anti-AVPR2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-AVPR2 antibody    WB~~1:2000
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 Western Blot (WB) of anti-AVPR2 antibody    All lanes : Anti-AVPR2 Antibody (C-term) at 1:2000 dilution
Lane 1: Hela whole cell lysates
Lane 2: Jurkat whole cell lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 40 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-AVPR2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AVPR2. It may not necessarily be applicable to this product.
 NCBI GI #    4557345
 NCBI GeneID    554
 NCBI Accession #    NP_000045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000054.4 [Other Products]
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 UniProt Primary Accession #    P30518 [Other Products]
 UniProt Secondary Accession #    O43192; Q3MJD3; Q9UCV9; C5HF20 [Other Products]
 UniProt Related Accession #    P30518 [Other Products]
 Molecular Weight    40279
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 NCBI Official Full Name    vasopressin V2 receptor isoform 1
 NCBI Official Synonym Full Names    arginine vasopressin receptor 2
 NCBI Official Symbol    AVPR2 [Similar Products]
 NCBI Official Synonym Symbols   
DI1; DIR; NDI; V2R; ADHR; DIR3
[Similar Products]
 NCBI Protein Information    vasopressin V2 receptor
 UniProt Protein Name    Vasopressin V2 receptor
 UniProt Synonym Protein Names   
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
 Protein Family    Vasopressin V2 receptor
 UniProt Gene Name    AVPR2 [Similar Products]
 UniProt Synonym Gene Names    ADHR; DIR; DIR3; V2R; V2R [Similar Products]
 UniProt Entry Name    V2R_HUMAN
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 NCBI Summary for AVPR2    This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AVPR2    AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; integral to membrane; plasma membrane; endosome

Molecular Function: protein binding; peptide binding; vasopressin receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; water transport; adenylate cyclase activation; positive regulation of systemic arterial blood pressure; excretion; cellular response to hormone stimulus; G-protein signaling, coupled to cAMP nucleotide second messenger; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; positive regulation of protein ubiquitination; hemostasis; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; renal water homeostasis; transmembrane transport

Disease: Nephrogenic Syndrome Of Inappropriate Antidiuresis; Diabetes Insipidus, Nephrogenic, X-linked
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Product References and Citations for anti-AVPR2 antibody

   Seibold A.,et al.Am. J. Hum. Genet. 51:1078-1083(1992).
Birnbaumer M.,et al.Nature 357:333-335(1992).
Wildin R.S.,et al.Am. J. Hum. Genet. 55:266-277(1994).
Fay M.J.,et al.Peptides 17:477-481(1996).
North W.G.,et al.Cancer Res. 58:1866-1871(1998).
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 Research Articles on AVPR2    1. Rescue of the N321K-V2R function by Val(4)-desmopressin action in nephrogenic diabetes insipidus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AVPR2 antibodyDiseases associated with anti-AVPR2 antibody
 Products by Pathway  Pathway Diagram
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 Disease Name  Pubmed Publications
 Diabetes Insipidus, Nephrogenic Antibodies  >106 publications with AVPR2 and Diabetes Insipidus, Nephrogenic
 Kidney Diseases Antibodies  >95 publications with AVPR2 and Kidney Diseases
 Polyuria Antibodies  >30 publications with AVPR2 and Polyuria
 Hyponatremia Antibodies  >19 publications with AVPR2 and Hyponatremia
 Genetic Diseases, X-Linked Antibodies  >17 publications with AVPR2 and Genetic Diseases, X-Linked
 Nephrogenic Syndrome of Inappropriate Antidiuresis Antibodies  >12 publications with AVPR2 and Nephrogenic Syndrome of Inappropriate Antidiuresis
 Inappropriate ADH Syndrome Antibodies  >11 publications with AVPR2 and Inappropriate ADH Syndrome
 Hypertension Antibodies  >2 publications with AVPR2 and Hypertension
 Neurobehavioral Manifestations Antibodies  >2 publications with AVPR2 and Neurobehavioral Manifestations
 Inflammation Antibodies  >2 publications with AVPR2 and Inflammation
Organs/Tissues associated with anti-AVPR2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with AVPR2 and Lung
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