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anti-AXL antibody :: Rabbit AXL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9503240
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AXL, Polyclonal Antibody

★Popular Item★
 Also Known As   

AXL (Phospho-Tyr691) Antibody

 Product Synonym Names    Adhesion-related kinase; ARK; AXL oncogene; kinase AXL; Tyrosine-protein kinase receptor UFO precursor; UFO
 Product Gene Name   

anti-AXL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M76125 mRNA
 3D Structure    ModBase 3D Structure for P30530
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    AXL (Phospho-Tyr691) Antibody detects endogenous levels of AXL only when phosphorylated at Tyr691.
 Purity/Purification    Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Target Modification    Phospho
 Modification Sites    H:Y691; M:Y692; R:Y692
 Immunogen    The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691.
 Immunogen Range    657-706
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 Preparation and Storage    Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-AXL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AXL antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-AXL antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000
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 Immunohistochemistry (IHC) of anti-AXL antibody    Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is blocked with the phospho peptide.
anti-AXL antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-AXL antibody    Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 15', using AXL (Phospho-Tyr691) Antibody. The lane on the right is blocked with the phospho peptide.
anti-AXL antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AXL. It may not necessarily be applicable to this product.
 NCBI GI #    21536468
 NCBI GeneID    558
 NCBI Accession #    NP_001690.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001699.5 [Other Products]
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 UniProt Primary Accession #    P30530 [Other Products]
 UniProt Secondary Accession #    Q8N5L2; Q9UD27 [Other Products]
 UniProt Related Accession #    P30530 [Other Products]
 Molecular Weight    97 kDa
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 NCBI Official Full Name    tyrosine-protein kinase receptor UFO isoform 2
 NCBI Official Synonym Full Names    AXL receptor tyrosine kinase
 NCBI Official Symbol    AXL [Similar Products]
 NCBI Official Synonym Symbols   
ARK; UFO; JTK11; Tyro7
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase receptor UFO
 UniProt Protein Name    Tyrosine-protein kinase receptor UFO
 UniProt Synonym Protein Names   
AXL oncogene
 Protein Family    Tyrosine-protein kinase receptor
 UniProt Gene Name    AXL [Similar Products]
 UniProt Synonym Gene Names    UFO [Similar Products]
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 NCBI Summary for AXL    The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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 UniProt Comments for AXL    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
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 Research Articles on AXL    1. The expression of MerTK and AxlTK varied according to the deposition of immunoglobulin and complements on glomeruli. Both MerTK and AxlTK expressions were increased on glomeruli and varied according to pathological classifications.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AXL antibodyDiseases associated with anti-AXL antibody
 Reference Product  PubMed Publications
 GAS6 antibody  >212 publications with AXL and GAS6
 SRC antibody  >20 publications with AXL and SRC
 GRB2 antibody  >8 publications with AXL and GRB2
 ADAM10 antibody  >3 publications with AXL and ADAM10
 TENC1 antibody  >3 publications with AXL and TENC1
 SOCS1 antibody  >3 publications with AXL and SOCS1
 PTPN11 antibody  >2 publications with AXL and PTPN11
 SHC1 antibody  >2 publications with AXL and SHC1
 LCK antibody  >1 publications with AXL and LCK
 CBL antibody  >1 publications with AXL and CBL
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >155 publications with AXL and Neoplasms
 Carcinoma Antibodies  >62 publications with AXL and Carcinoma
 Inflammation Antibodies  >47 publications with AXL and Inflammation
 Neoplasm Metastasis Antibodies  >31 publications with AXL and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >29 publications with AXL and Nervous System Diseases
 Adenocarcinoma Antibodies  >28 publications with AXL and Adenocarcinoma
 Disease Models, Animal Antibodies  >28 publications with AXL and Disease Models, Animal
 Lung Neoplasms Antibodies  >26 publications with AXL and Lung Neoplasms
 Breast Neoplasms Antibodies  >25 publications with AXL and Breast Neoplasms
 Necrosis Antibodies  >25 publications with AXL and Necrosis
Organs/Tissues associated with anti-AXL antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >76 publications with AXL and Vascular
 Brain Antibodies  >45 publications with AXL and Brain
 Eye Antibodies  >43 publications with AXL and Eye
 Muscle Antibodies  >40 publications with AXL and Muscle
 Lung Antibodies  >39 publications with AXL and Lung
 Kidney Antibodies  >38 publications with AXL and Kidney
 Bone Antibodies  >34 publications with AXL and Bone
 Bone Marrow Antibodies  >27 publications with AXL and Bone Marrow
 Liver Antibodies  >24 publications with AXL and Liver
 Embryonic Tissue Antibodies  >16 publications with AXL and Embryonic Tissue
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