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anti-ABL1 antibody :: Rabbit anti-Mouse Abl1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6005021 anti-ABL1 antibody
Unit / Price
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Abl1, Polyclonal Antibody

 Also Known As   

Abl1, ID (Abl1, Abl, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150)

 Product Synonym Names    Anti -Abl1, ID (Abl1, Abl, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150)
 Product Gene Name   

anti-ABL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (133588266..133763062). Location: 9q34.1
 OMIM    189980
 3D Structure    ModBase 3D Structure for P00519
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    Mouse
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ABL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ABL1 antibody

   Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
 Product Categories/Family for anti-ABL1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-ABL1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ABL1 antibody    Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
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NCBI/Uniprot data below describe general gene information for ABL1. It may not necessarily be applicable to this product.
 NCBI GI #    553164
 NCBI GeneID    25
 NCBI Accession #    AAA88012.1 [Other Products]
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 UniProt Primary Accession #    P00519 [Other Products]
 UniProt Secondary Accession #    Q13869; Q13870; Q16133; Q17R61; Q45F09; A3KFJ3 [Other Products]
 UniProt Related Accession #    P00519 [Other Products]
 Molecular Weight    122,873 Da [Similar Products]
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 NCBI Official Full Name    ABL1, partial
 NCBI Official Synonym Full Names    c-abl oncogene 1, non-receptor tyrosine kinase
 NCBI Official Symbol    ABL1 [Similar Products]
 NCBI Official Synonym Symbols   
ABL; JTK7; p150; c-ABL; v-abl; bcr/abl
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; Abelson tyrosine-protein kinase 1; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1
 UniProt Protein Name    Tyrosine-protein kinase ABL1
 UniProt Synonym Protein Names   
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    ABL1 [Similar Products]
 UniProt Synonym Gene Names    ABL; JTK7 [Similar Products]
 UniProt Entry Name    ABL1_HUMAN
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 NCBI Summary for ABL1    The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABL1    Abl: an ubiquitously expressed and highly conserved proto-oncogenic tyrosine kinase. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. Negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. It has been implicated in regulation of cell proliferation, differentiation, apoptosis, cell adhesion and stress response. The Philadephia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Inhibitors: Gleevec (imatinib, Glivec), Dasatinib. Two alternatively-spliced isoforms have been described.

Protein type: EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; Kinase, protein; TK group; Abl family

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: nucleoplasm; extrinsic to internal side of plasma membrane; nuclear membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; leading edge; nucleolus; cytosol; nucleus; actin cytoskeleton

Molecular Function: actin monomer binding; protein C-terminus binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; actin filament binding; protein binding; DNA binding; syntaxin binding; protein-tyrosine kinase activity; manganese ion binding; mitogen-activated protein kinase binding; nicotinate-nucleotide adenylyltransferase activity; SH3 domain binding; ATP binding; receptor binding

Biological Process: DNA damage induced protein phosphorylation; positive regulation of apoptosis; cerebellum morphogenesis; negative regulation of BMP signaling pathway; transitional one stage B cell differentiation; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; regulation of endocytosis; negative regulation of mitotic cell cycle; cell cycle arrest; neuromuscular process controlling balance; positive regulation of oxidoreductase activity; spleen development; mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-tyrosine phosphorylation; muscle cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of osteoblast proliferation; negative regulation of ubiquitin-protein ligase activity; autophagy; response to oxidative stress; actin cytoskeleton organization and biogenesis; axon guidance; peptidyl-tyrosine phosphorylation; alpha-beta T cell differentiation; platelet-derived growth factor receptor signaling pathway; mitochondrial depolarization; positive regulation of mitotic cell cycle; Bergmann glial cell differentiation; regulation of transcription, DNA-dependent; collateral sprouting; cell differentiation; B cell proliferation during immune response; regulation of cell adhesion; epidermal growth factor receptor signaling pathway; cell migration; mismatch repair; thymus development; B-1 B cell homeostasis; activated T cell proliferation; DNA damage response, signal transduction; protein modification process; regulation of cell proliferation; microspike biogenesis; innate immune response; positive regulation of muscle cell differentiation; regulation of autophagy; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of cell-cell adhesion; blood coagulation; response to DNA damage stimulus

Disease: Leukemia, Chronic Myeloid
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 Research Articles on ABL1    1. Data indicate that AMP-dependent kinases (AMPKalpha1 and AMPKalpha2) inhibit caveolin-1 phosphorylation by stabilizing the interaction between c-Abl and Prdx-1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Abl1, ID (Abl1, Abl, Tyrosine-protein kinase ABL1, Abelson murine leukemia vi
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 MBS7226756  Monkey CDK5 and ABL1 enzyme subste 2 (CABLES2) ELISA Kit  MBS8233861  ABL1 (pY204) Blocking Peptide
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 MBS7202863  Goat CDK5 and ABL1 enzyme subste 2 (CABLES2) ELISA Kit  MBS7222061  Monkey CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit
 MBS9407159  ABL1 Antibody  MBS9220291  Mouse Abl1 Antibody (Center) Blocking peptide
Products associated with anti-ABL1 antibodyPathways associated with anti-ABL1 antibody
 Reference Product  PubMed Publications
 BCR antibody  >602 publications with ABL1 and BCR
 SRC antibody  >38 publications with ABL1 and SRC
 GRB2 antibody  >8 publications with ABL1 and GRB2
 CBL antibody  >7 publications with ABL1 and CBL
 ABI1 antibody  >7 publications with ABL1 and ABI1
 CRKL antibody  >6 publications with ABL1 and CRKL
 CRK antibody  >5 publications with ABL1 and CRK
 RB1 antibody  >4 publications with ABL1 and RB1
 DOK1 antibody  >2 publications with ABL1 and DOK1
 ATM antibody  >1 publications with ABL1 and ATM
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-ABL1 antibodyOrgans/Tissues associated with anti-ABL1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >555 publications with ABL1 and Neoplasms
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >293 publications with ABL1 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >119 publications with ABL1 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >55 publications with ABL1 and Cell Transformation, Neoplastic
 Anemia Antibodies  >18 publications with ABL1 and Anemia
 Neoplasms, Experimental Antibodies  >14 publications with ABL1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >10 publications with ABL1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >9 publications with ABL1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >7 publications with ABL1 and Nervous System Diseases
 Fibrosis Antibodies  >6 publications with ABL1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >191 publications with ABL1 and Blood
 Bone Antibodies  >116 publications with ABL1 and Bone
 Bone Marrow Antibodies  >109 publications with ABL1 and Bone Marrow
 Prostate Antibodies  >10 publications with ABL1 and Prostate
 Spleen Antibodies  >9 publications with ABL1 and Spleen
 Brain Antibodies  >6 publications with ABL1 and Brain
 Muscle Antibodies  >5 publications with ABL1 and Muscle
 Lymph Antibodies  >5 publications with ABL1 and Lymph
 Lymph Node Antibodies  >5 publications with ABL1 and Lymph Node
 Lung Antibodies  >4 publications with ABL1 and Lung
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