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anti-ACACA antibody :: Rabbit Acetyl CoA Carboxylase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS620207 anti-ACACA antibody
Unit / Price
0.1 mL  /  $480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acetyl CoA Carboxylase 1 (ACACA), Polyclonal Antibody

 Also Known As   

Acetyl CoA Carboxylase 1 (ACAC, ACC, ACC1, ACCA, ACC-alpha, Acetyl-CoA carboxylase alpha)

 Product Synonym Names    Anti -Acetyl CoA Carboxylase 1 (ACAC, ACC, ACC1, ACCA, ACC-alpha, Acetyl-CoA carboxylase alpha)
 Product Gene Name   

anti-ACACA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (35441927..35766902, complement). Location: 17q21
 OMIM    200350
 3D Structure    ModBase 3D Structure for Q13085
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recongnizes endogenous levels of human total Acetyl CoA Carboxylase 1 protein. Species crossreactivity: mouse and rat.
 Purity/Purification    Affinity Purified
Purified by Protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA and 50% glycerol.
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 Immunogen    Synthetic peptide derived from the sequence of human acetyl-CoA carboxylase 1 protein conjugated to KLH.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ACACA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACACA antibody

   Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265kD ACCalpha (ACC1) is the predominant isoform found in liver, adipocytes and mammary gland, while the 280kD ACCbeta (ACC2) is the major isoform in skeletal muscle and heart (1). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (2). ACC is a potential target of anti-obesity drugs (3,4).
 Product Categories/Family for anti-ACACA antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-ACACA antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

 Application Notes for anti-ACACA antibody    Suitable for use in Western Blot, Immunofluorescence, and Immunoprecipitation.
Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunofluorescence (IC): 1:800
Immunoprecipitation: 1:50
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NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.
 NCBI GI #    38679960
 NCBI GeneID    31
 NCBI Accession #    NP_942131.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_198834.1 [Other Products]
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 UniProt Primary Accession #    Q13085 [Other Products]
 UniProt Secondary Accession #    Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68 [Other Products]
 UniProt Related Accession #    Q13085; Q59FY4; Q7Z562; Q7Z565; Q7Z5W8 [Other Products]
 Molecular Weight    265,554 Da [Similar Products]
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 NCBI Official Full Name    acetyl-CoA carboxylase 1 isoform 1
 NCBI Official Synonym Full Names    acetyl-CoA carboxylase alpha
 NCBI Official Symbol    ACACA [Similar Products]
 NCBI Official Synonym Symbols   
ACC; ACAC; ACC1; ACCA; ACACAD
[Similar Products]
 NCBI Protein Information    acetyl-CoA carboxylase 1; ACC-alpha; OTTHUMP00000164069; OTTHUMP00000164070; OTTHUMP00000164076; acetyl-Coenzyme A carboxylase alpha
 UniProt Protein Name    Acetyl-CoA carboxylase 1
 UniProt Synonym Protein Names   
ACC-alpha
 UniProt Gene Name    ACACA [Similar Products]
 UniProt Synonym Gene Names    ACAC; ACC1; ACCA [Similar Products]
 UniProt Entry Name    ACACA_HUMAN
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 NCBI Summary for ACACA    Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for ACACA    ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Ligase; Lipid Metabolism - fatty acid biosynthesis; EC 6.4.1.2; EC 6.3.4.14

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton

Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding

Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; positive regulation of cellular metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; cellular lipid metabolic process; carnitine shuttle; biotin metabolic process; protein homotetramerization; multicellular organismal protein metabolic process; tissue homeostasis; energy reserve metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process

Disease: Acetyl-coa Carboxylase Deficiency
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 Research Articles on ACACA    1. Transient over-expression of CREB1 in HepG2 cells activates ACC1 PII promoter and induces the production of triacylglycerol in response to arachidonic acid (AA), indicating that the effect of AA on ACC1 is possibly regulated via CREB1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACACA antibodyPathways associated with anti-ACACA antibody
 Reference Product  PubMed Publications
 PRKAA2 antibody  >1 publications with ACACA and PRKAA2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
Diseases associated with anti-ACACA antibodyOrgans/Tissues associated with anti-ACACA antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >7 publications with ACACA and Fatty Liver
 Obesity Antibodies  >4 publications with ACACA and Obesity
 Neoplasms Antibodies  >4 publications with ACACA and Neoplasms
 Metabolic Diseases Antibodies  >4 publications with ACACA and Metabolic Diseases
 Liver Diseases Antibodies  >3 publications with ACACA and Liver Diseases
 Insulin Resistance Antibodies  >3 publications with ACACA and Insulin Resistance
 Leukemia Antibodies  >2 publications with ACACA and Leukemia
 Leukemia, Myeloid, Acute Antibodies  >2 publications with ACACA and Leukemia, Myeloid, Acute
 Weight Gain Antibodies  >2 publications with ACACA and Weight Gain
 Leukemia, Myeloid Antibodies  >2 publications with ACACA and Leukemia, Myeloid
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >12 publications with ACACA and Adipose Tissue
 Liver Antibodies  >9 publications with ACACA and Liver
 Connective Tissue Antibodies  >8 publications with ACACA and Connective Tissue
 Blood Antibodies  >7 publications with ACACA and Blood
 Muscle Antibodies  >6 publications with ACACA and Muscle
 Mammary Gland Antibodies  >5 publications with ACACA and Mammary Gland
 Thyroid Antibodies  >2 publications with ACACA and Thyroid
 Ovary Antibodies  >2 publications with ACACA and Ovary
 Vascular Antibodies  >2 publications with ACACA and Vascular
 Embryonic Tissue Antibodies  >1 publications with ACACA and Embryonic Tissue
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