NP_001084.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
acetyl-CoA carboxylase 2
NCBI Official Synonym Full Names
acetyl-CoA carboxylase beta
NCBI Protein Information
acetyl-CoA carboxylase 2
UniProt Protein Name
Acetyl-CoA carboxylase 2
UniProt Synonym Protein Names
ACC-betaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14)
UniProt Synonym Gene Names
NCBI Summary for ACACb
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for ACACb
ACC2: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: cytosol; endomembrane system; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; metal ion binding; protein binding
Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; positive regulation of cellular metabolic process; protein homotetramerization; regulation of cholesterol biosynthetic process; response to drug; response to nutrient levels; response to organic cyclic compound
Research Articles on ACACb
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Products associated with anti-ACACb antibody
Pathways associated with anti-ACACb antibody
Diseases associated with anti-ACACb antibody
Organs/Tissues associated with anti-ACACb antibody
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