NP_066406.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,950 Da
NCBI Official Full Name
histone H2B type 1-B
NCBI Official Synonym Full Names
histone cluster 1 H2B family member b
NCBI Protein Information
histone H2B type 1-B
UniProt Protein Name
Histone H2B type 1-B
UniProt Synonym Protein Names
Histone H2B.1; Histone H2B.f; H2B/f
UniProt Synonym Gene Names
NCBI Summary for HIST1H2BB
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H2BB
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Research Articles on HIST1H2BB
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Pathways associated with anti-HIST1H2BB antibody
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