Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TNK2 rightarrow Polyclonal TNK2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Wingless Type MMTV Integration Site Family, Member 5B (WNT5B... ELISA Kit
 • Oxycodone Antibody
 • Haptoglobin (HP) ELISA Kit
 • Albumin Protein
 • ABHD14A Antibody
 • Lamin A (Ab-22) (LMNA) Antibody
 • leptin ELISA Kit
 • FN3K Antibody
 • lipoprotein alpha, Lp-alpha ELISA Kit
 • Pepsinogen II (Pepsinogen C) Purified Protein
 • TBX18 Antibody
 • Interleukin 6 (IL6) ELISA Kit
 • C-Terminal Connective Tissue Growth Factor (CCTGF) ELISA Kit
 • A4GALT siRNA
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TNK2 antibody :: Rabbit anti-Human Ack1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611868 anti-TNK2 antibody
Unit / Price
0.1 mL  /  $750 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ack1 (TNK2), Polyclonal Antibody

 Also Known As   

Ack1, phosphorylated (Tyr284) (TNK2, Tyrosine Kinase, non-receptor 2, Tyrosine Kinase non-receptor protein 2, ACK, ACK1, Activated CDC42 kinase 1, FLJ44758, FLJ45547, p21cdc42Hs)

 Product Synonym Names    Anti -Ack1, phosphorylated (Tyr284) (TNK2, Tyrosine Kinase, non-receptor 2, Tyrosine Kinase non-receptor protein 2, ACK, ACK1, Activated CDC42 kinase 1, FLJ44758, FLJ45547, p21cdc42Hs)
 Product Gene Name   

anti-TNK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 3; NC_000003.11 (195590236..195635880, complement). Location: 3q29
 OMIM    606994
 3D Structure    ModBase 3D Structure for Q07912
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    Recognizes human ACK1 phosphorylated at Tyrosine residue 284 at ~114kD.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.6, 0.1% sodium azide, 30% glycerol.
Section Bar
 Immunogen    Synthetic peptide corresponding to amino acids surrounding Tyr284 of human ACK1 conjugated to KLH.
Section Bar
 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TNK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-TNK2 antibody

   Ack1 and Ack2 (activated cdc42-associated kinase 1 and 2) are non-receptor tyrosine kinases that consist of a tyrosine kinase core, an SH3 domain, a cdc42/Rac-binding (CRIB) domain, a Ralt homology region and a proline-rich region. Ack1 and 2 are the only two tyrosine kinases known to interact with cdc42. Both Acks are activated by growth factors including EGF and PDGF, as well as by activated integrins through cell adhesion, and may serve to link receptor tyrosine kinase or G protein-coupled receptor signaling with cdc42. Acks may regulate cell growth, morphology and motility. Recent findings indicate that Ack1 may play a role in prostate tumorigenesis, making it a potential drug target for this type of cancer.
 Product Categories/Family for anti-TNK2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-TNK2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-TNK2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:10,000. Detects ACK1 phosphorylated on Tyrosine residue 284 in COS7 cells transfected with wild type ACK1 but not in COS7 cells transfected with ACK1(Y284F). Lysates from COS7 cells, transfected with either wild type ACK1 or mutant ACK1 (Y284F), were resolved by electrophoresis, transferred to PVDF (Immobilon-P), and probed with A0650-01 for 2 hours at RT. Proteins were visualized via HRP and chemiluminescent detection.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TNK2. It may not necessarily be applicable to this product.
 NCBI GI #    58331191
 NCBI GeneID    10188
 NCBI Accession #    NP_001010938.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001010938.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q07912 [Other Products]
 UniProt Secondary Accession #    Q6ZMQ0; Q8N6U7; Q96H59 [Other Products]
 UniProt Related Accession #    Q07912; Q59FX1 [Other Products]
 Molecular Weight    114,569 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    activated CDC42 kinase 1 isoform 2
 NCBI Official Synonym Full Names    tyrosine kinase, non-receptor, 2
 NCBI Official Symbol    TNK2 [Similar Products]
 NCBI Official Synonym Symbols   
ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs
[Similar Products]
 NCBI Protein Information    activated CDC42 kinase 1; ACK-1; OTTHUMP00000208563; OTTHUMP00000208564; OTTHUMP00000208565; OTTHUMP00000208566; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2
 UniProt Protein Name    Activated CDC42 kinase 1
 UniProt Synonym Protein Names   
Tyrosine kinase non-receptor protein 2
 Protein Family    Activated CDC42 kinase
 UniProt Gene Name    TNK2 [Similar Products]
 UniProt Synonym Gene Names    ACK1 [Similar Products]
 UniProt Entry Name    ACK1_HUMAN
Section Bar
 NCBI Summary for TNK2    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]
Section Bar
 UniProt Comments for TNK2    Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: Protein kinase, TK; EC 2.7.11.1; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Ack family

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasmic vesicle membrane; clathrin-coated vesicle; dendrite; coated pit; extrinsic to internal side of plasma membrane; growth cone; adherens junction; cell soma; membrane; axon; cytoplasm; plasma membrane; nucleus; endosome

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein-tyrosine kinase activity; WW domain binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; GTPase inhibitor activity; ATP binding; epidermal growth factor receptor binding; hormone receptor binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; cell migration; cell surface receptor linked signal transduction; small GTPase mediated signal transduction; negative regulation of catalytic activity; innate immune response; endocytosis; cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
Table BarTOPTable Bar
 Research Articles on TNK2    1. SNP rs2278034 in ACK1 is associated with IFN therapy outcome in patients with HCV. ACK1 may play a role in innate and IFN-induced antiviral action against HCV.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TNK2 antibodyPathways associated with anti-TNK2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >32 publications with TNK2 and CDC42
 EGFR antibody  >9 publications with TNK2 and EGFR
 WWOX antibody  >3 publications with TNK2 and WWOX
 MERTK antibody  >2 publications with TNK2 and MERTK
 MCF2 antibody  >2 publications with TNK2 and MCF2
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
Diseases associated with anti-TNK2 antibodyOrgans/Tissues associated with anti-TNK2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with TNK2 and Neoplasms
 Male Urogenital Diseases Antibodies  >7 publications with TNK2 and Male Urogenital Diseases
 Prostatic Neoplasms Antibodies  >6 publications with TNK2 and Prostatic Neoplasms
 Carcinoma Antibodies  >4 publications with TNK2 and Carcinoma
 Breast Neoplasms Antibodies  >3 publications with TNK2 and Breast Neoplasms
 Female Urogenital Diseases Antibodies  >2 publications with TNK2 and Female Urogenital Diseases
 Hyperplasia Antibodies  >2 publications with TNK2 and Hyperplasia
 Kidney Diseases Antibodies  >2 publications with TNK2 and Kidney Diseases
 Lung Neoplasms Antibodies  >2 publications with TNK2 and Lung Neoplasms
 Lymphoma Antibodies  >1 publications with TNK2 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >8 publications with TNK2 and Prostate
 Kidney Antibodies  >4 publications with TNK2 and Kidney
 Brain Antibodies  >4 publications with TNK2 and Brain
 Nerve Antibodies  >3 publications with TNK2 and Nerve
 Lung Antibodies  >2 publications with TNK2 and Lung
 Blood Antibodies  >2 publications with TNK2 and Blood
 Lymph Antibodies  >1 publications with TNK2 and Lymph
 Stomach Antibodies  >1 publications with TNK2 and Stomach
 Esophagus Antibodies  >1 publications with TNK2 and Esophagus
 Lymph Node Antibodies  >1 publications with TNK2 and Lymph Node
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions