ACJ24535.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,141 Da
NCBI Official Full Name
actinin alpha 1 isoform 3
NCBI Official Synonym Full Names
actinin alpha 1
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-actinin-1
UniProt Protein Name
Alpha-actinin-1
UniProt Synonym Protein Names
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
NCBI Summary for ACTN1
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTN1
ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q24.1|14q22-q24
Cellular Component: actin filament; cell projection; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; intercellular junction; intracellular; pseudopodium; ruffle; stress fiber
Molecular Function: actin filament binding; double-stranded RNA binding; integrin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; vinculin binding
Biological Process: actin filament network formation; actin filament organization; focal adhesion formation; negative regulation of cell motility; platelet activation; platelet degranulation; platelet formation
Disease: Bleeding Disorder, Platelet-type, 15
Research Articles on ACTN1
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Products associated with anti-ACTN1 antibody
Pathways associated with anti-ACTN1 antibody
Diseases associated with anti-ACTN1 antibody
Organs/Tissues associated with anti-ACTN1 antibody
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