EAW58151.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,295 Da
NCBI Official Full Name
activating transcription factor 1
NCBI Official Synonym Full Names
activating transcription factor 1
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-1
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-1
UniProt Synonym Protein Names
Activating transcription factor 1; Protein TREB36
UniProt Synonym Gene Names
NCBI Summary for ATF1
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
UniProt Comments for ATF1
ATF-1: a transcription factor that is a member of the leucine zipper family. Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Binds the Tax-responsive element (TRE) of HTLV-I. Activated downstream of IL-1. c-Src and TRAF6 are mediators of IL-1-induced AP-1 activation. Plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter
Research Articles on ATF1
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Products associated with anti-ATF1 antibody
Pathways associated with anti-ATF1 antibody
Diseases associated with anti-ATF1 antibody
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