AAH28599.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,663 Da
NCBI Official Full Name
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
NCBI Official Synonym Full Names
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
NCBI Protein Information
DCC-interacting protein 13-alpha
UniProt Protein Name
DCC-interacting protein 13-alpha
UniProt Synonym Protein Names
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
UniProt Synonym Gene Names
NCBI Summary for APPL1
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
UniProt Comments for APPL1
APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; NuRD complex; vesicle membrane
Molecular Function: identical protein binding; protein binding; protein kinase B binding
Biological Process: cell proliferation; insulin receptor signaling pathway; regulation of glucose import; signal transduction
Disease: Maturity-onset Diabetes Of The Young, Type 14
Research Articles on APPL1
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Products associated with anti-APPL1 antibody
Pathways associated with anti-APPL1 antibody
Diseases associated with anti-APPL1 antibody
Organs/Tissues associated with anti-APPL1 antibody
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