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anti-ADORA3 antibody :: Rabbit anti-Rat Adenosine A3 Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS613614 anti-ADORA3 antibody
Unit / Price
0.1 mL  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adenosine A3 Receptor (ADORA3), Polyclonal Antibody

 Also Known As   

Adenosine A3 Receptor (A3AR)

 Product Synonym Names    Anti -Adenosine A3 Receptor (A3AR)
 Product Gene Name   

anti-ADORA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (112025970..112106597, complement). Location: 1p13.2
 3D Structure    ModBase 3D Structure for Q6LD47
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Recognizes Adenosine A3 Receptor. Species crossreactivity: The peptide used for making antibodies to rat A3R shows 46% homology (7/15 AA) with human and 20% (3/15 AA) with sheep A3R sequences. Antibody crossreactivity in various species is not established.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid in 0.05% sodium azide, 40% glycerol.
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 Immunogen    A 15 amino acid sequence corresponding to rat A3R gene. This region corresponds to the 3rd extracellular domain.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ADORA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADORA3 antibody

   The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b and A3. The high affinity receptor A1 inhibits adenyl cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in the coronary artery. Various ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini and C-termini are predicted to be extracellular and cytoplasmic, respectively. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromosome 1).
 Product Categories/Family for anti-ADORA3 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-ADORA3 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ADORA3 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-1:50,000 using 50-100ng A3R control peptide per well.
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NCBI/Uniprot data below describe general gene information for ADORA3. It may not necessarily be applicable to this product.
 NCBI GI #    4262078
 NCBI GeneID    140
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 UniProt Primary Accession #    Q6LD47 [Other Products]
 UniProt Related Accession #    P33765; Q5QNZ3; Q5QNZ4; Q6LD47; Q6P2N6; Q9HBK8 [Other Products]
 Molecular Weight    847 Da [Similar Products]
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 NCBI Official Full Name    adenosine A3 receptor
 NCBI Official Synonym Full Names    adenosine A3 receptor
 NCBI Official Symbol    ADORA3 [Similar Products]
 NCBI Official Synonym Symbols   
A3AR; AD026; bA552M11.5; RP11-552M11.7
[Similar Products]
 NCBI Protein Information    adenosine receptor A3; OTTHUMP00000013476; OTTHUMP00000013479; OTTHUMP00000013739; OTTHUMP00000082917
 UniProt Protein Name    Adenosine A3 receptor protein
 Protein Family    Adenosine receptor
 UniProt Gene Name    adenosine A3 receptor [Similar Products]
 UniProt Entry Name    Q6LD47_HUMAN
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 NCBI Summary for ADORA3    This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for ADORA3    ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: mast cell granule; integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
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 Research Articles on ADORA3    1. results suggest that the high-transcript haplotype, ht1 (TC), of the ADORA3 gene may contribute to the development of cutaneous hyper-reactivity to aspirin, leading to the clinical presentation of aspirin-induced urticaria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADORA3 antibodyDiseases associated with anti-ADORA3 antibody
 Products by Pathway  Pathway Diagram
 Adenosine P1 Receptors Pathway antibodies  Adenosine P1 Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nucleotide GPCRs Pathway antibodies  Nucleotide GPCRs Pathway Diagram
 Disease Name  Pubmed Publications
 Ischemia Antibodies  >159 publications with ADORA3 and Ischemia
 Inflammation Antibodies  >111 publications with ADORA3 and Inflammation
 Heart Diseases Antibodies  >92 publications with ADORA3 and Heart Diseases
 Myocardial Ischemia Antibodies  >88 publications with ADORA3 and Myocardial Ischemia
 Kidney Diseases Antibodies  >76 publications with ADORA3 and Kidney Diseases
 Brain Diseases Antibodies  >75 publications with ADORA3 and Brain Diseases
 Necrosis Antibodies  >64 publications with ADORA3 and Necrosis
 Asthma Antibodies  >52 publications with ADORA3 and Asthma
 Lung Diseases Antibodies  >39 publications with ADORA3 and Lung Diseases
 Myocardial Infarction Antibodies  >37 publications with ADORA3 and Myocardial Infarction
Organs/Tissues associated with anti-ADORA3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >193 publications with ADORA3 and Blood
 Brain Antibodies  >191 publications with ADORA3 and Brain
 Heart Antibodies  >160 publications with ADORA3 and Heart
 Kidney Antibodies  >119 publications with ADORA3 and Kidney
 Lung Antibodies  >69 publications with ADORA3 and Lung
 Eye Antibodies  >32 publications with ADORA3 and Eye
 Nerve Antibodies  >27 publications with ADORA3 and Nerve
 Bone Antibodies  >26 publications with ADORA3 and Bone
 Testis Antibodies  >21 publications with ADORA3 and Testis
 Intestine Antibodies  >20 publications with ADORA3 and Intestine
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