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anti-AHCY antibody :: Rabbit anti-Human Adenosylhomocysteinase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489480 anti-AHCY antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adenosylhomocysteinase (AHCY), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Adenosylhomocysteinase polyclonal Antibody, FITC

 Product Synonym Names    S-adenosyl-L-homocysteine hydrolase; SAHH
 Product Gene Name   

anti-AHCY antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180960
 3D Structure    ModBase 3D Structure for P23526
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    FITC
 Immunogen    Recombinant human Adenosylhomocysteinase protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55758 / sc-55759
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-AHCY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AHCY antibody

   Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
 Applications Tested/Suitable for anti-AHCY antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.
 NCBI GI #    9951915
 NCBI GeneID    191
 NCBI Accession #    NP_000678.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000687.2 [Other Products]
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 UniProt Primary Accession #    P23526 [Other Products]
 UniProt Secondary Accession #    Q96A36; A8K307; B3KUN3; E1P5P2; F5H737 [Other Products]
 UniProt Related Accession #    P23526 [Other Products]
 Molecular Weight    44,659 Da
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 NCBI Official Full Name    adenosylhomocysteinase isoform 1
 NCBI Official Synonym Full Names    adenosylhomocysteinase
 NCBI Official Symbol    AHCY [Similar Products]
 NCBI Official Synonym Symbols   
SAHH; adoHcyase
[Similar Products]
 NCBI Protein Information    adenosylhomocysteinase
 UniProt Protein Name    Adenosylhomocysteinase
 UniProt Synonym Protein Names   
S-adenosyl-L-homocysteine hydrolase
 Protein Family    Adenosylhomocysteinase
 UniProt Gene Name    AHCY [Similar Products]
 UniProt Synonym Gene Names    SAHH; AdoHcyase [Similar Products]
 UniProt Entry Name    SAHH_HUMAN
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 NCBI Summary for AHCY    S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
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 UniProt Comments for AHCY    SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.

Protein type: Hydrolase; Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; melanosome; neuron projection; nucleus

Molecular Function: adenosylhomocysteinase activity; adenyl nucleotide binding; identical protein binding; NAD binding; protein binding

Biological Process: chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; methylation; one-carbon compound metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle; selenium metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process

Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
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 Research Articles on AHCY    1. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AHCY antibodyPathways associated with anti-AHCY antibody
 Reference Product  PubMed Publications
 MAT1A antibody  >6 publications with AHCY and MAT1A
 BHMT antibody  >6 publications with AHCY and BHMT
 CBS antibody  >5 publications with AHCY and CBS
 MTRR antibody  >4 publications with AHCY and MTRR
 MAT2A antibody  >4 publications with AHCY and MAT2A
 MTR antibody  >4 publications with AHCY and MTR
 DNMT1 antibody  >1 publications with AHCY and DNMT1
 CTH antibody  >1 publications with AHCY and CTH
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway antibodies  Metabolism Of Ingested SeMet, Sec, MeSec Into H2Se Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
Diseases associated with anti-AHCY antibodyOrgans/Tissues associated with anti-AHCY antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with AHCY and Liver Diseases
 Necrosis Antibodies  >4 publications with AHCY and Necrosis
 Disease Models, Animal Antibodies  >4 publications with AHCY and Disease Models, Animal
 Fatty Liver Antibodies  >3 publications with AHCY and Fatty Liver
 Nervous System Diseases Antibodies  >3 publications with AHCY and Nervous System Diseases
 Hepatitis Antibodies  >3 publications with AHCY and Hepatitis
 Cardiovascular Diseases Antibodies  >3 publications with AHCY and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with AHCY and Inflammation
 Amino Acid Metabolism, Inborn Errors Antibodies  >2 publications with AHCY and Amino Acid Metabolism, Inborn Errors
 Edema Antibodies  >1 publications with AHCY and Edema
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with AHCY and Blood
 Liver Antibodies  >14 publications with AHCY and Liver
 Brain Antibodies  >4 publications with AHCY and Brain
 Embryonic Tissue Antibodies  >3 publications with AHCY and Embryonic Tissue
 Muscle Antibodies  >3 publications with AHCY and Muscle
 Ovary Antibodies  >2 publications with AHCY and Ovary
 Kidney Antibodies  >2 publications with AHCY and Kidney
 Heart Antibodies  >2 publications with AHCY and Heart
 Mammary Gland Antibodies  >1 publications with AHCY and Mammary Gland
 Intestine Antibodies  >1 publications with AHCY and Intestine
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