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anti-ADIPOQ antibody :: Rabbit Adiponectin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150072
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adiponectin (ADIPOQ), Polyclonal Antibody

 Also Known As   

Adiponectin Antibody

 Product Synonym Names    Adiponectin; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; ACDC; Adiponectin; 30 kDa adipocyte complement-related protein; adiponectin, C1Q and collagen domain containing
 Product Gene Name   

anti-ADIPOQ antibody

[Similar Products]
 Antibody/Peptide Pairs    Adiponectin peptide (MBS153006) is used for blocking the activity of Adiponectin antibody (MBS150072)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612556
 3D Structure    ModBase 3D Structure for Q15848
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Adiponectin Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Adiponectin antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human adiponectin.
 Buffer    Adiponectin Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    Adiponectin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ADIPOQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADIPOQ antibody

   Adiponectin Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases.
 Applications Tested/Suitable for anti-ADIPOQ antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ADIPOQ antibody    Adiponectin antibody can be used for the detection of adiponectin by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ADIPOQ antibody    Western blot analysis of adiponectin in HL60 cell lysate with adiponectin antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
anti-ADIPOQ antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ADIPOQ antibody    Immunohistochemistry of adiponectin in rat brain tissue with adiponectin antibody at 10 μg/mL.
anti-ADIPOQ antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ADIPOQ antibody    Immunofluorescence of Adiponectin in Rat Brain cells with Adiponectin antibody at 10 μg/mL.
anti-ADIPOQ antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ADIPOQ. It may not necessarily be applicable to this product.
 NCBI GI #    4757760
 NCBI GeneID    9370
 NCBI Accession #    NP_004788 [Other Products]
 NCBI GenBank Nucleotide #    NM_004797.3 [Other Products]
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 UniProt Primary Accession #    Q15848 [Other Products]
 UniProt Secondary Accession #    Q58EX9 [Other Products]
 UniProt Related Accession #    Q15848 [Other Products]
 Molecular Weight    Predicted: 27 kDa

Observed: 26 kDa
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 NCBI Official Full Name    adiponectin
 NCBI Official Synonym Full Names    adiponectin, C1Q and collagen domain containing
 NCBI Official Symbol    ADIPOQ [Similar Products]
 NCBI Official Synonym Symbols   
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
[Similar Products]
 NCBI Protein Information    adiponectin; gelatin-binding protein 28; adipose specific collagen-like factor; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein
 UniProt Protein Name    Adiponectin
 UniProt Synonym Protein Names   
30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein
 Protein Family    Adiponectin
 UniProt Gene Name    ADIPOQ [Similar Products]
 UniProt Synonym Gene Names    ACDC; ACRP30; APM1; GBP28; ACRP30; apM-1 [Similar Products]
 UniProt Entry Name    ADIPO_HUMAN
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 NCBI Summary for ADIPOQ    This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
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 UniProt Comments for ADIPOQ    adiponectin: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex). Synthesized exclusively by adipocytes and secreted into plasma.

Protein type: Endoplasmic reticulum; Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; collagen; cell surface; endoplasmic reticulum; extracellular region

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; hormone activity; cytokine activity; sialic acid binding; receptor binding

Biological Process: circadian rhythm; negative regulation of MAP kinase activity; negative regulation of phagocytosis; negative regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; response to glucocorticoid stimulus; membrane hyperpolarization; positive regulation of cellular protein metabolic process; negative regulation of smooth muscle cell migration; glucose homeostasis; negative regulation of granulocyte differentiation; positive regulation of interleukin-8 production; positive regulation of glucose import; negative regulation of gluconeogenesis; response to glucose stimulus; adiponectin-mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of blood pressure; negative regulation of cell migration; response to nutrient; protein homooligomerization; generation of precursor metabolites and energy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of signal transduction; negative regulation of heterotypic cell-cell adhesion; glucose metabolic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of tumor necrosis factor production; negative regulation of fat cell differentiation; negative regulation of synaptic transmission; response to sucrose stimulus; membrane depolarization; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; positive regulation of fatty acid metabolic process; fatty acid beta-oxidation; negative regulation of low-density lipoprotein receptor biosynthetic process; cellular response to insulin stimulus; negative regulation of macrophage differentiation; negative regulation of inflammatory response; response to hypoxia; brown fat cell differentiation; fatty acid oxidation; response to activity; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of myeloid cell apoptosis; positive regulation of blood pressure

Disease: Adiponectin, Serum Level Of, Quantitative Trait Locus 1
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 Research Articles on ADIPOQ    1. Reduced total adiponectin expression is associated with glucose intolerance and gestational diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADIPOQ antibodyPathways associated with anti-ADIPOQ antibody
 Reference Product  PubMed Publications
 PPARG antibody  >128 publications with ADIPOQ and PPARG
 ADIPOR1 antibody  >116 publications with ADIPOQ and ADIPOR1
 ADIPOR2 antibody  >101 publications with ADIPOQ and ADIPOR2
 LEP antibody  >36 publications with ADIPOQ and LEP
 FABP4 antibody  >29 publications with ADIPOQ and FABP4
 INS antibody  >8 publications with ADIPOQ and INS
 CEBPB antibody  >3 publications with ADIPOQ and CEBPB
 WNT10B antibody  >1 publications with ADIPOQ and WNT10B
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-ADIPOQ antibodyOrgans/Tissues associated with anti-ADIPOQ antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >635 publications with ADIPOQ and Insulin Resistance
 Obesity Antibodies  >592 publications with ADIPOQ and Obesity
 Cardiovascular Diseases Antibodies  >422 publications with ADIPOQ and Cardiovascular Diseases
 Diabetes Mellitus Antibodies  >381 publications with ADIPOQ and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >265 publications with ADIPOQ and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >263 publications with ADIPOQ and Inflammation
 Necrosis Antibodies  >195 publications with ADIPOQ and Necrosis
 Heart Diseases Antibodies  >187 publications with ADIPOQ and Heart Diseases
 Atherosclerosis Antibodies  >166 publications with ADIPOQ and Atherosclerosis
 Metabolic Syndrome X Antibodies  >152 publications with ADIPOQ and Metabolic Syndrome X
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >457 publications with ADIPOQ and Adipose Tissue
 Heart Antibodies  >162 publications with ADIPOQ and Heart
 Kidney Antibodies  >65 publications with ADIPOQ and Kidney
 Brain Antibodies  >63 publications with ADIPOQ and Brain
 Intestine Antibodies  >12 publications with ADIPOQ and Intestine
 Skin Antibodies  >10 publications with ADIPOQ and Skin
 Nerve Antibodies  >10 publications with ADIPOQ and Nerve
 Testis Antibodies  >3 publications with ADIPOQ and Testis
 Mammary Gland Antibodies  >2 publications with ADIPOQ and Mammary Gland
 Thymus Antibodies  >1 publications with ADIPOQ and Thymus
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