NP_653345.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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Molecular Weight
26,410 Da
NCBI Official Full Name
adiponectin
NCBI Official Synonym Full Names
adiponectin, C1Q and collagen domain containing
NCBI Official Synonym Symbols
NCBI Protein Information
adiponectin
UniProt Protein Name
30 kDa adipocyte complement-related protein
UniProt Synonym Protein Names
30 kDa adipocyte complement-related protein
NCBI Summary for ADP
adipocyte complement-related factor that plays a role in obesity-related insulin resistance [RGD, Feb 2006]
UniProt Comments for ADP
adiponectin: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex). Synthesized exclusively by adipocytes and secreted into plasma.
Protein type: Endoplasmic reticulum; Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: cell surface; collagen; endoplasmic reticulum; extracellular space; perinuclear region of cytoplasm; protein complex
Molecular Function: hormone activity; identical protein binding; protein homodimerization activity; receptor binding; sialic acid binding
Biological Process: adiponectin-activated signaling pathway; brown fat cell differentiation; cellular response to insulin stimulus; circadian rhythm; fatty acid beta-oxidation; fatty acid oxidation; glucose homeostasis; glucose metabolic process; membrane depolarization; membrane hyperpolarization; negative regulation of blood pressure; negative regulation of cell migration; negative regulation of fat cell differentiation; negative regulation of gluconeogenesis; negative regulation of granulocyte differentiation; negative regulation of heterotypic cell-cell adhesion; negative regulation of hormone secretion; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; negative regulation of low-density lipoprotein receptor biosynthetic process; negative regulation of macrophage differentiation; negative regulation of MAP kinase activity; negative regulation of phagocytosis; negative regulation of protein autophosphorylation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of synaptic transmission; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of blood pressure; positive regulation of cellular protein metabolic process; positive regulation of fatty acid metabolic process; positive regulation of glucose import; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-8 production; positive regulation of myeloid cell apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of signal transduction; protein homooligomerization; response to activity; response to drug; response to ethanol; response to glucocorticoid stimulus; response to glucose stimulus; response to hypoxia; response to nutrient; response to nutrient levels; response to sucrose
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Products associated with anti-ADP antibody
Pathways associated with anti-ADP antibody
Diseases associated with anti-ADP antibody
Organs/Tissues associated with anti-ADP antibody
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