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anti-PLIN2 antibody :: Guinea Pig Adipophilin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534652 anti-PLIN2 antibody
Unit / Price
0.1 mL  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adipophilin (PLIN2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Adipophilin antibody

 Product Synonym Names    Polyclonal Adipophilin; Anti-Adipophilin
 Product Gene Name   

anti-PLIN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    103195
 3D Structure    ModBase 3D Structure for Q99541
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 Clonality    Polyclonal
 Host    Guinea Pig
 Species Reactivity    Human, mouse, rat, dog, and bovine. Reactivity with cultured cell lines: Caco, PLC, HaCat, SV80, RD125, Huvec, RV, PC-12, MDCK. Negative with glioma
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 Specificity    Human adipophilin
 Purity/Purification    Whole antiserum
 Form/Format    Whole antiserum with 0.09% Sodium Azide
 Concentration    100ul per vial (lot specific)
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 Biological Significance    Adipophilin / ADRP (a member of the PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al.; for review see e.g. Targett-Adams et al.); inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin).
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-PLIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLIN2 antibody

   Guinea Pig polyclonal Adipophilin antibody
 Product Categories/Family for anti-PLIN2 antibody    Cancer
 Applications Tested/Suitable for anti-PLIN2 antibody   

Immunohistochemistry (IHC), Immunoblotting

 Application Notes for anti-PLIN2 antibody    Immunohistochemistry: 1:100
Immunoblotting: 1:2,000
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NCBI/Uniprot data below describe general gene information for PLIN2. It may not necessarily be applicable to this product.
 NCBI GI #    1806040
 NCBI GeneID    123
 NCBI Accession #    CAA65989.1 [Other Products]
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 UniProt Primary Accession #    Q99541 [Other Products]
 UniProt Secondary Accession #    Q9BSC3 [Other Products]
 UniProt Related Accession #    Q99541 [Other Products]
 Molecular Weight    48,075 Da [Similar Products]
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 NCBI Official Full Name    adipophilin, partial
 NCBI Official Synonym Full Names    perilipin 2
 NCBI Official Symbol    PLIN2 [Similar Products]
 NCBI Official Synonym Symbols   
ADFP; ADRP
[Similar Products]
 NCBI Protein Information    perilipin-2
 UniProt Protein Name    Perilipin-2
 UniProt Synonym Protein Names   
Adipophilin; Adipose differentiation-related protein; ADRP
 Protein Family    Perilipin
 UniProt Gene Name    PLIN2 [Similar Products]
 UniProt Synonym Gene Names    ADFP; ADRP [Similar Products]
 UniProt Entry Name    PLIN2_HUMAN
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 NCBI Summary for PLIN2    The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for PLIN2    perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: endoplasmic reticulum; plasma membrane; extracellular region; lipid particle; cytosol; nucleus

Biological Process: long-chain fatty acid transport; response to drug; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance
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Product References and Citations for anti-PLIN2 antibody

   Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones; Jie Donga, Tammy Tonga, Amanda M. Reynadoa, Jeffrey M. Rosenb, Shixia Huangb, Yi Li (Developmental Biology: Volume: 346 Issue: 2 Page: 196-203 DOI: 10.1016/j.ydbio.2010.07.027)
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 Research Articles on PLIN2    1. Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLIN2 antibodyPathways associated with anti-PLIN2 antibody
 Reference Product  PubMed Publications
 PNPLA2 antibody  >4 publications with PLIN2 and PNPLA2
 PPARA antibody  >2 publications with PLIN2 and PPARA
 CARM1 antibody  >1 publications with PLIN2 and CARM1
 MED1 antibody  >1 publications with PLIN2 and MED1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Diseases associated with anti-PLIN2 antibodyOrgans/Tissues associated with anti-PLIN2 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >15 publications with PLIN2 and Fatty Liver
 Liver Diseases Antibodies  >7 publications with PLIN2 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with PLIN2 and Kidney Diseases
 Inflammation Antibodies  >5 publications with PLIN2 and Inflammation
 Adenocarcinoma Antibodies  >4 publications with PLIN2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with PLIN2 and Cardiovascular Diseases
 Atrophy Antibodies  >2 publications with PLIN2 and Atrophy
 Breast Neoplasms Antibodies  >2 publications with PLIN2 and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with PLIN2 and Fibrosis
 Weight Loss Antibodies  >1 publications with PLIN2 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >25 publications with PLIN2 and Muscle
 Liver Antibodies  >18 publications with PLIN2 and Liver
 Blood Antibodies  >13 publications with PLIN2 and Blood
 Adipose Tissue Antibodies  >12 publications with PLIN2 and Adipose Tissue
 Bone Antibodies  >7 publications with PLIN2 and Bone
 Kidney Antibodies  >5 publications with PLIN2 and Kidney
 Mammary Gland Antibodies  >5 publications with PLIN2 and Mammary Gland
 Connective Tissue Antibodies  >4 publications with PLIN2 and Connective Tissue
 Skin Antibodies  >3 publications with PLIN2 and Skin
 Heart Antibodies  >3 publications with PLIN2 and Heart
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