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anti-PNPLA2 antibody :: Rabbit anti-Human Adipose Triglyceride Lipase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611367 anti-PNPLA2 antibody
Unit / Price
0.1 mL  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adipose Triglyceride Lipase (PNPLA2), Polyclonal Antibody

 Also Known As   

Adipose Triglyceride Lipase (ATGL, Desnutrin, Phospholipase A2 zeta)

 Product Synonym Names    Anti -Adipose Triglyceride Lipase (ATGL, Desnutrin, Phospholipase A2 zeta)
 Product Gene Name   

anti-PNPLA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (818901..825573). Location: 11p15.5
 OMIM    609059
 3D Structure    ModBase 3D Structure for Q96AD5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human ATGL.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.05% sodium azide.
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 Immunogen    Synthetic peptide within the C-terminal region [aa400-500] of the human ATGL protein [NCBI# NP_005171]
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-PNPLA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PNPLA2 antibody

   Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
 Product Categories/Family for anti-PNPLA2 antibody    Antibodies; Abs to Enzymes, Phospholipase
 Applications Tested/Suitable for anti-PNPLA2 antibody   

Western Blot (WB)

 Application Notes for anti-PNPLA2 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml
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NCBI/Uniprot data below describe general gene information for PNPLA2. It may not necessarily be applicable to this product.
 NCBI GI #    58759051
 NCBI GeneID    57104
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 UniProt Primary Accession #    Q96AD5 [Other Products]
 UniProt Secondary Accession #    O60643; Q5EFF5; Q6XYE5; Q96ET6; Q9NQ61; Q9NQ62 [Other Products]
 UniProt Related Accession #    Q96AD5 [Other Products]
 Molecular Weight    55,316 Da [Similar Products]
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 NCBI Official Full Name    adipose triglyceride lipase
 NCBI Official Synonym Full Names    patatin-like phospholipase domain containing 2
 NCBI Official Symbol    PNPLA2 [Similar Products]
 NCBI Official Synonym Symbols   
ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; DKFZp667M109; 1110001C14Rik
[Similar Products]
 NCBI Protein Information    patatin-like phospholipase domain-containing protein 2; TTS2.2; desnutrin; IPLA2-zeta; OTTHUMP00000164432; triglyceride hydrolase; adipose triglyceride lipase; transport-secretion protein 2.2; pigment epithelium-derived factor; calcium-independent phospholipase A2
 UniProt Protein Name    Patatin-like phospholipase domain-containing protein 2
 UniProt Synonym Protein Names   
Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2
 Protein Family    Patatin-like phospholipase domain-containing protein
 UniProt Gene Name    PNPLA2 [Similar Products]
 UniProt Synonym Gene Names    ATGL [Similar Products]
 UniProt Entry Name    PLPL2_HUMAN
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 NCBI Summary for PNPLA2    This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq]
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 UniProt Comments for PNPLA2    PNPLA2: the rate-limiting lipolytic enzyme in mammals, flies, and yeast. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Upregulated by exercise training in human skeletal muscle. Has acylglycerol transacylase activity. May act coordinately with HSL within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Interacting with ABHD5 stimulates its triglyceride hydrolase activity. Despite a colocalization in lipid droplets, it probably does not interact with perilipin. Transcriptionally regulated by FOXO1A. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.3; Lipase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane; plasma membrane; lipid particle; cytosol

Molecular Function: triacylglycerol lipase activity

Biological Process: sequestering of lipid; phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process

Disease: Neutral Lipid Storage Disease With Myopathy
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 Research Articles on PNPLA2    1. total lipase, ATGL and HSL activities were higher in visceral white adipose tissue of cancer patients compared with individuals without cancer and higher in cancer patients with cachexia compared with cancer patients without cachexia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PNPLA2 antibodyDiseases associated with anti-PNPLA2 antibody
 Products by Pathway  Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Triacylglyceride Synthesis Pathway antibodies  Triacylglyceride Synthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Obesity Antibodies  >15 publications with PNPLA2 and Obesity
 Genetic Diseases, Inborn Antibodies  >14 publications with PNPLA2 and Genetic Diseases, Inborn
 NEUTRAL LIPID STORAGE DISEASE WITH MYOPATHY Antibodies  >13 publications with PNPLA2 and NEUTRAL LIPID STORAGE DISEASE WITH MYOPATHY
 Muscular Diseases Antibodies  >11 publications with PNPLA2 and Muscular Diseases
 Fatty Liver Antibodies  >9 publications with PNPLA2 and Fatty Liver
 Insulin Resistance Antibodies  >8 publications with PNPLA2 and Insulin Resistance
 Liver Diseases Antibodies  >6 publications with PNPLA2 and Liver Diseases
 Congenital Abnormalities Antibodies  >5 publications with PNPLA2 and Congenital Abnormalities
 Lipidoses Antibodies  >4 publications with PNPLA2 and Lipidoses
 Neoplasms Antibodies  >4 publications with PNPLA2 and Neoplasms
Organs/Tissues associated with anti-PNPLA2 antibody
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >20 publications with PNPLA2 and Adipose Tissue
 Blood Antibodies  >14 publications with PNPLA2 and Blood
 Muscle Antibodies  >14 publications with PNPLA2 and Muscle
 Liver Antibodies  >12 publications with PNPLA2 and Liver
 Connective Tissue Antibodies  >12 publications with PNPLA2 and Connective Tissue
 Skin Antibodies  >5 publications with PNPLA2 and Skin
 Eye Antibodies  >4 publications with PNPLA2 and Eye
 Ovary Antibodies  >3 publications with PNPLA2 and Ovary
 Heart Antibodies  >2 publications with PNPLA2 and Heart
 Kidney Antibodies  >2 publications with PNPLA2 and Kidney
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