NP_001919.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
complement factor D preproprotein
NCBI Official Synonym Full Names
complement factor D (adipsin)
NCBI Protein Information
complement factor D
UniProt Protein Name
Complement factor D
UniProt Synonym Protein Names
Adipsin; C3 convertase activator; Properdin factor D
UniProt Synonym Gene Names
UniProt Entry Name
CFAD_HUMAN
NCBI Summary for CFD
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
UniProt Comments for CFD
CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.46; Secreted; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; extracellular region
Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: platelet activation; platelet degranulation; complement activation, alternative pathway; innate immune response; blood coagulation; proteolysis; complement activation
Disease: Complement Factor D Deficiency
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Products associated with anti-CFD antibody
Pathways associated with anti-CFD antibody
Diseases associated with anti-CFD antibody
Organs/Tissues associated with anti-CFD antibody
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