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anti-ADRA2A antibody :: Rabbit Adrenergic Receptor, Alpha 2a Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS619330 anti-ADRA2A antibody
Unit / Price
0.1 mL  /  $870 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adrenergic Receptor, Alpha 2a (ADRA2A), Polyclonal Antibody

 Also Known As   

Adrenergic Receptor, Alpha 2a (A2aAR)

 Product Synonym Names    Anti -Adrenergic Receptor, Alpha 2a (A2aAR)
 Product Gene Name   

anti-ADRA2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (112836790..112840665). Location: 10q24-q26
 OMIM    104210
 3D Structure    ModBase 3D Structure for P08913
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human A2aAR. at~45kD. Species Crossreactivity
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.05% sodium azide, before the addition of glycerol to 40%.
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 Immunogen    Synthetic peptide corresponding to aa218-235 [RIYQIAKRRTRVPPSRRG] of human A2aAR. This sequence is completely conserved in mouse, rat and porcine A2aAR.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ADRA2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADRA2A antibody

   Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins.
 Product Categories/Family for anti-ADRA2A antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-ADRA2A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADRA2A antibody    Suitable for use in Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (paraffin sections): 1:500
Western Blot: 1:250
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NCBI/Uniprot data below describe general gene information for ADRA2A. It may not necessarily be applicable to this product.
 NCBI GI #    194353970
 NCBI GeneID    150
 NCBI Accession #    NP_000672.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000681.3 [Other Products]
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 UniProt Primary Accession #    P08913 [Other Products]
 UniProt Secondary Accession #    Q2I8G2; Q2XN99; Q86TH8; Q9BZK1; B0LPF6 [Other Products]
 UniProt Related Accession #    P08913 [Other Products]
 Molecular Weight    48,957 Da [Similar Products]
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 NCBI Official Full Name    alpha-2A adrenergic receptor
 NCBI Official Synonym Full Names    adrenergic, alpha-2A-, receptor
 NCBI Official Symbol    ADRA2A [Similar Products]
 NCBI Official Synonym Symbols   
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR
[Similar Products]
 NCBI Protein Information    alpha-2A adrenergic receptor; OTTHUMP00000020485; alpha-2A adrenoceptor; alpha-2AAR subtype C10; alpha-2A adrenoreceptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type
 UniProt Protein Name    Alpha-2A adrenergic receptor
 UniProt Synonym Protein Names   
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor
 Protein Family    Alpha-2A adrenergic receptor
 UniProt Gene Name    ADRA2A [Similar Products]
 UniProt Synonym Gene Names    ADRA2R; ADRAR [Similar Products]
 UniProt Entry Name    ADA2A_HUMAN
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 NCBI Summary for ADRA2A    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
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 UniProt Comments for ADRA2A    ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; synapse; receptor complex

Molecular Function: protein binding; protein homodimerization activity; alpha-2C adrenergic receptor binding; protein heterodimerization activity; thioesterase binding; alpha2-adrenergic receptor activity; alpha-1B adrenergic receptor binding; norepinephrine binding; epinephrine binding; protein kinase binding; heterotrimeric G-protein binding

Biological Process: fear response; negative regulation of calcium ion-dependent exocytosis; positive regulation of potassium ion transport; female pregnancy; thermoception; signal transduction; positive regulation of vasodilation; glucose homeostasis; positive regulation of membrane protein ectodomain proteolysis; Rho protein signal transduction; negative regulation of insulin secretion; intestinal absorption; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; negative regulation of lipid catabolic process; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; DNA replication; positive regulation of cytokine production; platelet activation; negative regulation of calcium ion transport; activation of protein kinase B; negative regulation of adenylate cyclase activity; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; regulation of vasoconstriction; Ras protein signal transduction; activation of protein kinase activity; energy reserve metabolic process; negative regulation of epinephrine secretion; cell motility; blood coagulation; actin cytoskeleton organization and biogenesis; regulation of insulin secretion; acute inflammatory response; positive regulation of cell migration
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 Research Articles on ADRA2A    1. we did not find a significant association between the 1291-C/G polymorphism in the ADRA2A gene and prevalence of the metabolic syndrome in psychiatric patients using antipsychotics
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRA2A antibodyPathways associated with anti-ADRA2A antibody
 Reference Product  PubMed Publications
 ADRB1 antibody  >480 publications with ADRA2A and ADRB1
 ADRBK1 antibody  >15 publications with ADRA2A and ADRBK1
 GNAI2 antibody  >2 publications with ADRA2A and GNAI2
 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-ADRA2A antibodyOrgans/Tissues associated with anti-ADRA2A antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >636 publications with ADRA2A and Hypertension
 Pain Antibodies  >443 publications with ADRA2A and Pain
 Central Nervous System Diseases Antibodies  >280 publications with ADRA2A and Central Nervous System Diseases
 Hypotension Antibodies  >216 publications with ADRA2A and Hypotension
 Neoplasms Antibodies  >153 publications with ADRA2A and Neoplasms
 Bradycardia Antibodies  >136 publications with ADRA2A and Bradycardia
 Tachycardia Antibodies  >135 publications with ADRA2A and Tachycardia
 Heart Failure Antibodies  >118 publications with ADRA2A and Heart Failure
 Myocardial Ischemia Antibodies  >88 publications with ADRA2A and Myocardial Ischemia
 Inflammation Antibodies  >88 publications with ADRA2A and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3024 publications with ADRA2A and Brain
 Heart Antibodies  >1157 publications with ADRA2A and Heart
 Nerve Antibodies  >1055 publications with ADRA2A and Nerve
 Kidney Antibodies  >566 publications with ADRA2A and Kidney
 Intestine Antibodies  >269 publications with ADRA2A and Intestine
 Eye Antibodies  >233 publications with ADRA2A and Eye
 Connective Tissue Antibodies  >222 publications with ADRA2A and Connective Tissue
 Pancreas Antibodies  >126 publications with ADRA2A and Pancreas
 Adrenal Gland Antibodies  >118 publications with ADRA2A and Adrenal Gland
 Stomach Antibodies  >108 publications with ADRA2A and Stomach
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