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anti-Adrb1 antibody :: Goat Adrenergic Receptor, beta 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622362 anti-Adrb1 antibody
Unit / Price
0.1 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adrenergic Receptor, beta 1 (Adrb1), Polyclonal Antibody

 Also Known As   

Adrenergic Receptor, beta 1 (ADRB1, ADRB1R, B1AR, BETA1AR, RHR, beta-1-adrenergic receptor)

 Product Synonym Names    Anti -Adrenergic Receptor, beta 1 (ADRB1, ADRB1R, B1AR, BETA1AR, RHR, beta-1-adrenergic receptor)
 Product Gene Name   

anti-Adrb1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000085.5 (56796862..56799352). Location: 19 D2; 19 51.0 cM
 3D Structure    ModBase 3D Structure for P34971
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Canine, Human, Mouse, Rat
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 Specificity    Recognizes human ADRB1 at ~55kD in human heart lysates (calculated MW of 51.2kDa according to NP_000675.1). Species Crossreactivity: Canine, mouse and rat.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
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 Immunogen    Synthetic peptide corresponding to human ADRB1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Adrb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Adrb1 antibody

   Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism. In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system. Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.
 Product Categories/Family for anti-Adrb1 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-Adrb1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-Adrb1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:128000
Western Blot: 0.3-1ug/ml
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NCBI/Uniprot data below describe general gene information for Adrb1. It may not necessarily be applicable to this product.
 NCBI GI #    187955951
 NCBI GeneID    11554
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 UniProt Primary Accession #    P34971 [Other Products]
 UniProt Secondary Accession #    B2RVY4 [Other Products]
 UniProt Related Accession #    P34971; Q9CRR2 [Other Products]
 Molecular Weight    50,494 Da [Similar Products]
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 NCBI Official Full Name    Adrenergic receptor, beta 1
 NCBI Official Synonym Full Names    adrenergic receptor, beta 1
 NCBI Official Symbol    Adrb1 [Similar Products]
 NCBI Official Synonym Symbols   
Adrb-1; beta-AR
[Similar Products]
 NCBI Protein Information    beta-1 adrenergic receptor; beta 1-AR; beta-1 adrenoceptor; beta-1 adrenoreceptor; cardiac beta adrenergic receptor
 UniProt Protein Name    Beta-1 adrenergic receptor
 UniProt Synonym Protein Names   
Beta-1 adrenoreceptor
 Protein Family    Beta-1 adrenergic receptor
 UniProt Gene Name    Adrb1 [Similar Products]
 UniProt Synonym Gene Names    Adrb1r [Similar Products]
 UniProt Entry Name    ADRB1_MOUSE
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 UniProt Comments for Adrb1    ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Cellular Component: membrane; intracellular membrane-bound organelle; cytoplasm; early endosome; plasma membrane; integral to membrane; nucleus; endosome

Molecular Function: drug binding; norepinephrine binding; epinephrine binding; alpha-2A adrenergic receptor binding; PDZ domain binding; beta1-adrenergic receptor activity; G-protein coupled receptor activity; signal transducer activity; protein binding; adrenoceptor activity; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: fear response; diet induced thermogenesis; wound healing; positive regulation of apoptosis; apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; signal transduction; sensory perception of pain; positive regulation of saliva secretion; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; positive regulation of adenylate cyclase activity; negative regulation of multicellular organism growth; glycogen catabolic process; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of heart rate; regulation of calcium ion transport; memory; G-protein coupled receptor protein signaling pathway; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of heart contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
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 Research Articles on Adrb1    1. b1-adrenoceptors are the predominant b-adrenoceptor in mouse astrocytes and are primarily responsible for cAMP production in response to b-adrenoceptor stimulation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Adrb1 antibodyDiseases associated with anti-Adrb1 antibody
 Products by Pathway  Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1059 publications with Adrb1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >896 publications with Adrb1 and Heart Diseases
 Heart Failure Antibodies  >536 publications with Adrb1 and Heart Failure
 Hypertension Antibodies  >314 publications with Adrb1 and Hypertension
 Cardiomegaly Antibodies  >235 publications with Adrb1 and Cardiomegaly
 Cardiomyopathies Antibodies  >220 publications with Adrb1 and Cardiomyopathies
 Myocardial Ischemia Antibodies  >207 publications with Adrb1 and Myocardial Ischemia
 Cardiomyopathy, Dilated Antibodies  >198 publications with Adrb1 and Cardiomyopathy, Dilated
 Arrhythmias, Cardiac Antibodies  >168 publications with Adrb1 and Arrhythmias, Cardiac
 Tachycardia Antibodies  >156 publications with Adrb1 and Tachycardia
Organs/Tissues associated with anti-Adrb1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >562 publications with Adrb1 and Brain
 Lung Antibodies  >286 publications with Adrb1 and Lung
 Intestine Antibodies  >89 publications with Adrb1 and Intestine
 Eye Antibodies  >70 publications with Adrb1 and Eye
 Embryonic Tissue Antibodies  >40 publications with Adrb1 and Embryonic Tissue
 Spinal Cord Antibodies  >20 publications with Adrb1 and Spinal Cord
 Thymus Antibodies  >7 publications with Adrb1 and Thymus
 Mammary Gland Antibodies  >1 publications with Adrb1 and Mammary Gland
 Extraembryonic Tissue Antibodies  >1 publications with Adrb1 and Extraembryonic Tissue
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