NP_001012656.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7,883 Da
NCBI Official Full Name
adrenocortical dysplasia protein isoform 1
NCBI Official Synonym Full Names
adrenocortical dysplasia
NCBI Protein Information
adrenocortical dysplasia protein
UniProt Protein Name
Adrenocortical dysplasia protein
UniProt Comments for ACD
ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8 D3|8 53.04 cM
Cellular Component: chromosome; chromosome, telomeric region; nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleus
Molecular Function: DNA binding; protein binding; telomeric DNA binding
Biological Process: embryonic limb morphogenesis; intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; segmentation; skeletal system development; telomere assembly; telomere capping; telomere maintenance; urogenital system development
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Pathways associated with anti-ACD antibody
Diseases associated with anti-ACD antibody
Organs/Tissues associated with anti-ACD antibody
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